6566 RESULTS
Sort By:
At CTAD, all eyes were on the anti-amyloid antibody donanemab, which is before the FDA. Scientists showed how Phase 3 is enrolling, and how plasma tau enables wholly remote inclusion of people with plaques and tangles.
Once p-tau217 in cerebrospinal fluid reaches a tipping point, it rises at a constant rate in everyone and predicts the age when symptoms will begin.
The iPSC Neurodegenerative Disease Institute proposes a reference iPSC line to standardize research between labs.
In one, the N-terminus was highly structured. In the other, the N-terminus was disordered, similar to Aβ peptides found in the brain parenchyma.
p-S129syn better binds its synaptic vesicle protein partners than does plain α-synuclein.
Data from six countries showed prescriptions for antipsychotic drugs rose in 2020, and remain high.
The protein binds to segments of tau that are prone to aggregate, preventing tangles and neurodegeneration.
As it moves from the neutral pH of the cell surface to the acidic environs of the endosome, LRP2 switches its conformation from ligand receiver to dumper.
Adeno-associated viruses carrying Cas9 and guide RNAs cut hexanucleotide repeats out of the C9ORF gene. RNA inclusions and poly-dipeptides became sparse.
In the Alzheimer’s brain, too, plaques trigger a coordinated inflammatory response from microglia and astrocytes. A preprint paper had shown the same for mice.
Scientists turned iPSCs from people with ALS or Parkinson’s into motor neurons or dopaminergic neurons, respectively, then characterized them with a plethora of multi-omics.
These endoplasmic reticulum channels can flood the cytosol with calcium, disrupting lysosomal acidification and stalling autophagy.
Changing the mix of extracellular ions can put neurons to sleep and swell the brain interstitial fluid for better solute flow.
The p-tau217/tau217 ratio in the cerebrospinal fluid tightly correlated with amyloid, while p-tau205/tau205 best detected neurofibrillary tangles and neurodegeneration.
Volunteers who practiced daily slow-breathing exercises for a month lowered Aβ42 in their blood; could this diminish the risk of AD?
No filters selected
