Is Your Brain Aging Fast? Plasma Proteins Might Tell
Eight proteins in blood associate with faster brain aging, five with slower. The extracellular matrix protein brevican comes with larger cortical volume, lower dementia odds.
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Do CSF and Plasma NfL Diverge After Alzheimer’s Disease Onset?
After symptoms of autosomal-dominant AD start, the uptick in neurofilament light chain accelerates in CSF but tapers in plasma.
'Presymptomatic AD' or 'Asymptomatic at Risk'? Dx Criteria Disagree
Alzheimer’s Association diagnostic criteria favor the former term, International Working Group the latter, for cognitively healthy people with AD biomarkers.
In Familial Alzheimer’s, β-Synuclein Rises in Blood a Decade Before Onset
In ADAD mutation carriers, blood β-synuclein crept up after their amyloid-PET scans had turned positive, but before axons degenerated. Does it reflect crumbling synapses?
Some Alzheimer’s Blood Tests Are Racing Toward IVD Certification
Vendors of plasma p-tau217-based tests are filing with U.S. and European regulators for approval of fully automated, in vitro diagnostics.
Biomarkers Suggest Black and Hispanic People Less Likely to Have Amyloid
The findings suggest that non-AD pathologies, driven by other comorbidities, might contribute to cognitive decline in these populations.
X-Chromosome-Wide Association Data Spot Alzheimer’s Loci
XWAS from three research groups identified a dozen genetic loci that may help explain sex differences in AD.
Damage to the Gut Mucosa May Almost Double Parkinson's Risk
A retrospective study finds that gut damage precedes Parkinson’s disease onset, independent of bacterial infection.
Questions, Questions for Donanemab, Lecanemab
As immunotherapies enter care, scientists explore when to stop them, how amyloid removal relates to cognitive benefit, and whether fluid markers will track both plaque and tangles responses.
NULISA—A New Proteomic Method to Revamp Biomarker Analysis
Alzheimer’s markers are quantifiable in dried plasma, simplifying future diagnoses. With new ultrasensitive assays, hundreds of proteins could be analyzed this way.
A Finger-Prick Test for Alzheimer’s Disease?
Markers for AD can be measured in dried blood. This could greatly simplify diagnosis in far-flung areas. With new ultrasensitive assays, hundreds of proteins could be tested this way.
In Head-to-Head Testing, P-Tau217/Tau217 Comes Out on Top. By a Hair.
The percentage of tau fragments phosphorylated at amino acid 217 best pegged people with brain amyloid or tangles. The ratio’s edge over other markers is slight, though.
By Setting Standards, Experts Aim to Tame a Wild West of AD Blood Tests
An expert panel has laid out performance standards on amyloid tests. Clinical context will dictate accuracy, and online calculators might help.
A Plasma Test for Tangles?
In blood, fragments of tau containing the microtubule binding region could help diagnose dementia due to Alzheimer’s disease.
Are Alzheimer’s Blood Tests Ready for Primary Care?
Plasma p-tau217/tau217, alone or with Aβ42/40, identified people with amyloid pathology more accurately than did expert clinical assessment.
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