A Biological Definition of Parkinson’s Disease: Two Proposals Pave the Way
With newly available fluid biomarkers that detect α-synuclein pathology in the brain, researchers articulate ways to classify the disease based on its biology.
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Posterior Cortical Atrophy Is a Form of Young-Onset Alzheimer’s
Among 1,092 people with PCA, symptoms started around age 60, and 94 percent had amyloid plaques or neurofibrillary tangles.
AD Blood Tests Are Here. Now, Let's Grapple With How to Use Them
Scientists around the globe are studying how best to deploy Alzheimer's plasma tests in the real world. Their focus: primary care.
Paper Alert: p-Tau217 Blood Test Predicts Plaques, Tangles Over Time
ALZpath’s assay detected an annual rise in plasma phospho-tau217 in amyloid-positive people, with the steepest increase in those who also have tangles.
Per Simoa, CSF p-tau205 Tracks with Tangles, Disease Progression
The biomarker may signal tau’s early days of entanglement, and serve as a useful disease staging indicator, according to a new immunoassay.
Mind the GAP—Synaptic Protein in CSF Signals Tau Spread
Growth-associated protein 43 in the CSF identified people who accumulated tangles fastest. These spread through connected brain regions.
2023—A Bumper Year for the Treatment and Science of Alzheimer's
Last summer saw a first: the traditional approval of a disease-modifying Alzheimer's therapy. Solid progress on biomarkers, and a flourishing of basic research, made for a good year.
Heart Failure Drug Drastically Skews Blood Aβ
In people on Entresto, Aβ42 and Aβ40 shot up over six months. The Aβ42/40 ratio fell by a third.
At Holloway Summit, FTD Imaging Shows New Vista
PET tracers for the two main proteopathies of FTD, tau and TDP-43, are now in trials, while AI-enabled analysis of FDG-PET scans discriminates between diseases.
Second Holloway Summit Showcases Intense Search for FTD Biomarkers
Scientists have identified potential fluid and imaging markers that could discriminate between the two main proteopathies of FTD, tau and TDP-43.
Can Organ Aging Clock Foretell Cognitive Decline?
Proteins in human blood flag organ-specific accelerated aging and disease risk. For cognition, 49 proteins better predicted decline then did plasma p-tau 181.
And Then There Were Five: CSF Proteomics Defines Alzheimer’s Subtypes
Each associates with distinct AD risk variants, brain atrophy, and disease severity.
Two New p-Tau217 Blood Tests Join a Crowded Field
C2N’s PrecivityAD2 and ALZpath Inc.’s p-tau217 immunoassay identify people with AD with good accuracy.
Plasma p-Tau-217 Assays Work Well, But No Home Run for Diagnosis
For a diagnostic test, specificity and sensitivity fall a little shy. Using two cut points might solve the problem.
New Alzheimer’s Diagnostic Criteria Remain ‘Research Only’
This clarification comes after geriatricians argued that diagnosing AD in people without symptoms is premature, and the NIH pulled its name.
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