8 RESULTS
COMMENT Smyth et al. present several new observations about the nature and function of the meningeal layers surrounding the brain. Using transcriptomic data, they generated new mouse models to visualize and study anatomical structures that function as routes acro
COMMENT The meninges, a multilayered membrane structure that covers the surface of the brain and spinal cord, acts as a barrier to prevent uncontrolled molecular exchange and contributes to immune surveillance of the central nervous system. However, the cellular
COMMENT This interesting study, suggesting that medin promotes vascular amyloid accumulation in AD, expands on the authors’ and others’ previous work. Using two mouse models of Aβ amyloidosis, and bolstered by human data and structural data, the authors have achi
COMMENT Vasoactive properties of peptides have been known for more than 20 years. For example, in the mid-1990s Aβ peptides were shown to induce vasoconstriction in the isolated rat aorta, which was ameliorated by superoxide dismutase 1 (SOD1) implicating involve
COMMENT In 1787, anatomist Paolo Mascagni published an atlas of all lymphatic vessels in the human body, which included the brain, where he described the presence of lymphatics in the cerebral dura mater (Mascagni, 1787, Vasorum Lymphaticorum Corporis Humani Hist
COMMENT Park and colleagues have put together an elegant study that links activation of perivascular macrophages (PVMs) with known effects of Aβ on vascular function. Importantly, they have identified PVMs as cells responsible for a significant portion of reactiv
COMMENT Damisah et al. identified an incredibly useful methodology using Nissl dye NeuroTrace 500/525 to specifically label pericytes in vivo, which will more easily allow investigation of pericytes in the living brain. They should be congratulated for this outst
COMMENT In response to Dr. Grutzendler’s comments, we would like to emphasize that two recent exceptional
