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Lysosomal Protein TMEM106b Is Tightly Linked to TDP-43, Tau Pathology

RESEARCH NEWS 2024-10-31 Research News TMEM106b’s rap sheet is growing. Some of its genetic variants are linked to both Alzheimer’s disease and frontotemporal dementia, and fibrils of this lysosomal protein accumulate in several neurodegenerative diseases. Now, in an October 18 p

Some Plasma Proteins Bolster Phagocytosis and Metabolism in Microglia

RESEARCH NEWS 2024-10-29 Research News Far from a static barrier, the brain’s extensive interface with the blood is increasingly being appreciated as an active border, one that serves not only to keep some proteins out, but to let others in (Oct 2024 conference news). Once across

Amyloid Plaques Turn More Toxic as They Age

RESEARCH NEWS 2024-10-25 Research News How exactly do amyloid plaques affect surrounding brain tissue, and does this change over time? Scientists led by Jörg Hanrieder at the University of Gothenburg, Sweden, tackled this question by using isotopically labeled Aβ to timestamp pla

New Role for Tau: Making Lipid Droplets in Glia?

RESEARCH NEWS 2024-10-22 Research News Recent studies suggest that when neurons are overwhelmed by oxidative stress, they spew out toxic, peroxidated lipids. Glia then sail in to mop up the spill, containing the oils within intracellular droplets for use later on as fuel. Tau pla

Can Heparin Delay Alzheimer’s Disease?

RESEARCH NEWS 2024-10-20 Research News A drug that has been used for nearly a century to prevent and dissolve blood clots may also delay the onset of Alzheimer’s disease, according to a study in the October 8 Molecular Psychiatry. Heparin may never be prescribed for AD, but the f

Data Fabrication Ousted NIA Neuroscience Director Eliezer Masliah

COMMUNITY NEWS 2024-10-17 Community News A top researcher’s fall from grace sends shock waves through the scientific community. Such is the case with neuropathologist Eliezer Masliah, who stands accused of image falsification spanning 26 years. Masliah has published more than 800

Large Neuropathology GWAS Finds Four New Dementia Genes

RESEARCH NEWS 2024-10-17 Research News Geneticists are increasingly turning to endophenotypes, i.e., measurable disease traits, to help uncover genes that might be missed in heterogenous clinical cohorts. In the October 8 Nature Genetics, scientists led by David Fardo at the Univ

Repeat Expansion Mutations More Common Than Thought

RESEARCH NEWS 2024-10-17 Research News Repeat expansion disorders, which are responsible for more than 40 neurological diseases, may be more common than clinical data would suggest. Epidemiological studies had estimated that REDs affect about one in 3,000 people, but now a study

Do Overloaded Microglia Smother Stressed Neurons?

RESEARCH NEWS 2024-10-14 Research News In neurodegenerative diseases, microglia can help or harm the brain. In the October 3 Journal of Clinical Investigation, scientists led by Ilia Baskakov at the University of Maryland School of Medicine, Baltimore, documented a transition fro

Human Evolution Offers Clues to Frontotemporal Dementia

RESEARCH NEWS 2024-10-11 Research News Frontotemporal dementia (FTD) often strikes our most human traits, such as the ability to speak and to interact on social and emotional levels. Now, research led by Lorenzo Pasquini and William Seeley at the University of California, San Fra

Chimeric Protein Dephosphorylates Tau, Improves Memory

RESEARCH NEWS 2024-10-06 Research News Scientists are exploring many ways to tackle tau pathology. In the October 17 Cell Chemical Biology, researchers led by Jian-Zhi Wang at the Huazhong University of Science and Technology, Wuhan, China, advocated for a new one. They generated

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