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Neil Vasdev on Autopsies Confirm That PI-2620 Binds 4R Tau Deposits

COMMENT 18F PI-2620 was developed to image aggregated tau with mixed 3- and 4-microtuble-binding repeat domains (3R- and 4R-tau) in patients with Alzheimer’s disease (AD), and has recently been applied to patients with 4R-tauopathies, such as progressive supranuc

PAPER Slemann L, Gnorich J, Hummel S, Bartos LM, Klaus C, Kling A, Kusche-Palenga J, Kunte ST, Kunze LH, Englert AL, Li Y, Vogler L, Katzdobler S, Palleis C, Bernhardt A, Jäck A, Zwergal A, Hopfner F, Romer S, Biechele G, Stocklein S, Bischof G, vanEimeren T, Drzezga A, Sabri O, Barthel H, Respondek G, Grimmer T, Levin J, Herms J, Paeger L, Willroider M, Beyer L, Hoglinger GU, Roeber S, Franzmeier N, Brendel M

Neuronal and oligodendroglial but not astroglial tau translates to in vivo tau-PET signals in primary tauopathies

bioRxiv2024.05.04.592508 .

Neil Vasdev


Centre for Addiction and Mental Health & University of Toronto
Toronto, Canada

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