PAPER Yoon JH, Gorospe M
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PAPER Etherton-Beer CD
Vascular cognitive impairment in dementia.
Maturitas. 2014 Oct;79(2):220-6. Epub 2014 Jun 14 PubMed.PAPER Bencherif M, Narla ST, Stachowiak MS
Alpha7 neuronal nicotinic receptor: a pluripotent target for diseases of the central nervous system.
CNS Neurol Disord Drug Targets. 2014;13(5):836-45. PubMed.Rodney Guttmann
University of West FloridaPensacola
Rodney Guttmann on Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice.
COMMENT The work by Rao and colleagues highlights the importance of proteolytic dynamics in neurodegeneration, placing the calcium-dependent protease, calpain, in the center of the universe. Evidence for calpain involvement in neurodegeneration has grown in the l
Peter Davies on Specific calpain inhibition by calpastatin prevents tauopathy and neurodegeneration and restores normal lifespan in tau P301L mice.
COMMENT This is a nice paper, and perhaps the only issue I see is that the authors choose to use a very mild pathology model, the heterozygous P301L mouse. The effects of calpain inhibition were significant in this model, but I would argue that to compare the eff
PAPER Fragkouli A, Tsilibary EC, Tzinia AK
Neuroprotective role of MMP-9 overexpression in the brain of Alzheimer's 5xFAD mice.
Neurobiol Dis. 2014 Oct;70:179-89. Epub 2014 Jul 6 PubMed.PAPER Dzamko N, Zhou J, Huang Y, Halliday GM
Parkinson's disease-implicated kinases in the brain; insights into disease pathogenesis.
Front Mol Neurosci. 2014;7:57. Epub 2014 Jun 24 PubMed.PAPER Games D, Valera E, Spencer B, Rockenstein E, Mante M, Adame A, Patrick C, Ubhi K, Nuber S, Sacayon P, Zago W, Seubert P, Barbour R, Schenk D, Masliah E
Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models.
J Neurosci. 2014 Jul 9;34(28):9441-54. PubMed.PAPER Vargas KJ, Makani S, Davis T, Westphal CH, Castillo PE, Chandra SS
Synucleins regulate the kinetics of synaptic vesicle endocytosis.
J Neurosci. 2014 Jul 9;34(28):9364-76. PubMed.PAPER Spencer B, Emadi S, Desplats P, Eleuteri S, Michael S, Kosberg K, Shen J, Rockenstein E, Patrick C, Adame A, Gonzalez T, Sierks M, Masliah E
ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo.
Mol Ther. 2014 Oct;22(10):1753-67. Epub 2014 Jul 10 PubMed.PAPER Schwartz JC, Podell ER, Han SS, Berry JD, Eggan KC, Cech TR
FUS is sequestered in nuclear aggregates in ALS patient fibroblasts.
Mol Biol Cell. 2014 Sep 1;25(17):2571-8. Epub 2014 Jul 9 PubMed.PAPER Lu CH, Petzold A, Topping J, Allen K, Macdonald-Wallis C, Clarke J, Pearce N, Kuhle J, Giovannoni G, Fratta P, Sidle K, Fish M, Orrell R, Howard R, Greensmith L, Malaspina A
Plasma neurofilament heavy chain levels and disease progression in amyotrophic lateral sclerosis: insights from a longitudinal study.
J Neurol Neurosurg Psychiatry. 2014 Jul 9; PubMed.PAPER Abdulla S, Vielhaber S, Kollewe K, Machts J, Heinze HJ, Dengler R, Petri S
The impact of physical impairment on emotional well-being in ALS.
Amyotroph Lateral Scler Frontotemporal Degener. 2014 Sep;15(5-6):392-7. Epub 2014 Jul 10 PubMed.PAPER Sher RB, Heiman-Patterson TD, Blankenhorn EA, Jiang J, Alexander G, Deitch JS, Cox GA
A major QTL on mouse chromosome 17 resulting in lifespan variability in SOD1-G93A transgenic mouse models of amyotrophic lateral sclerosis.
Amyotroph Lateral Scler Frontotemporal Degener. 2014 Dec;15(7-8):588-600. Epub 2014 Jul 10 PubMed.Current Filters
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