PAPER Holmes HM, Hayley DC, Alexander GC, Sachs GA

Reconsidering medication appropriateness for patients late in life.

Arch Intern Med. 2006 Mar 27;166(6):605-9. PubMed: 16567597

Twin Study Suggests Environment Modifies Genetic Risk for ALS

RESEARCH NEWS 2014-09-19 Research News Twins who came to an ALS Clinic in Toronto were identical down to the repeats in their C9ORF72 genes, except one had amyotrophic lateral sclerosis and the other did not. The mismatch suggests environmental influences modified the twins’ risk

PAPER Pamphlett R, Cheong PL, Trent RJ, Yu B

Can ALS-associated C9orf72 repeat expansions be diagnosed on a blood DNA test alone?

PLoS One. 2013;8(7):e70007. Print 2013 PubMed: 23894576

Alick Tan

Malayka Rahman

Alzheimer's Society
London, United Kingdom

Hemilton Brian

PAPER Yu CJ, Liu W, Chen HY, Wang L, Zhang ZR

BACE1 RNA interference improves spatial memory and attenuates Aβ burden in a streptozotocin-induced tau hyperphosphorylated rat model.

Cell Biochem Funct. 2014 Oct;32(7):590-6. Epub 2014 Sep 17 PubMed: 25230339

PAPER Shaikh S, Rizvi SM, Hameed N, Biswas D, Khan M, Shakil S, Kamal MA

Aptiom (eslicarbazepine acetate) as a dual inhibitor of β-secretase and voltage-gated sodium channel: advancement in Alzheimer's disease-epilepsy linkage via an enzoinformatics study.

CNS Neurol Disord Drug Targets. 2014;13(7):1258-62. PubMed: 25230222

PAPER Chowhan RK, Mittal S, Dar TA, Kamal MA, Singh LR

Ignored avenues in alpha-synuclein associated proteopathy.

CNS Neurol Disord Drug Targets. 2014;13(7):1246-57. PubMed: 25230221

PAPER Huss A, Spoerri A, Egger M, Kromhout H, Vermeulen R, For The Swiss National Cohort

Occupational exposure to magnetic fields and electric shocks and risk of ALS: The Swiss National Cohort.

Amyotroph Lateral Scler Frontotemporal Degener. 2014 Sep 17;:1-6. PubMed: 25229273

PAPER Agam G, Israelson A

Why lithium studies for ALS treatment should not be halted prematurely.

Front Neurosci. 2014;8:267. Epub 2014 Sep 2 PubMed: 25228854

PAPER Ayers JI, Fromholt S, Sinyavskaya O, Siemienski Z, Rosario AM, Li A, Crosby KW, Cruz PE, DiNunno NM, Janus C, Ceballos-Diaz C, Borchelt DR, Golde TE, Chakrabarty P, Levites Y

Widespread and efficient transduction of spinal cord and brain following neonatal AAV injection and potential disease modifying effect in ALS mice.

Mol Ther. 2015 Jan;23(1):53-62. Epub 2014 Sep 17 PubMed: 25228069

PAPER Menon P, Kiernan MC, Vucic S

Cortical hyperexcitability precedes lower motor neuron dysfunction in ALS.

Clin Neurophysiol. 2014 Aug 28; PubMed: 25227219

PAPER Ashraf GM, Greig NH, Khan TA, Hassan I, Tabrez S, Shakil S, Sheikh IA, Zaidi SK, Akram M, Jabir NR, Firoz CK, Naeem A, Alhazza IM, Damanhouri GA, Kamal MA

Protein misfolding and aggregation in Alzheimer's disease and type 2 diabetes mellitus.

CNS Neurol Disord Drug Targets. 2014;13(7):1280-93. PubMed: 25230234

PAPER Apetz N, Munch G, Govindaraghavan S, Gyengesi E

Natural compounds and plant extracts as therapeutics against chronic inflammation in Alzheimer's disease--a translational perspective.

CNS Neurol Disord Drug Targets. 2014;13(7):1175-91. PubMed: 25230232