Nikolaos K. Robakis on Hypercholesterolemia and Alzheimer's Disease: Unraveling the Connection and Assessing the Efficacy of Lipid-Lowering Therapies.

COMMENT This review article on hypercholesterolemia and Alzheimer's disease is an excellent contribution to understanding the complex link between cholesterol management and AD pathology, providing valuable insights for both clinicians and researchers. Here

ALIA-1758

THERAPEUTICS AbbVie Immunotherapy (passive) Amyloid-Related In May 2024, Aliada began Phase 1 with a single-dose trial in healthy participants. It will test the safety, tolerability, and pharmacokinetics of intravenous or subcutaneous doses of ALIA-1785 against endpoi

Donanemab: Small Tweak in Titration, Big Gain in Safety?

CONFERENCE COVERAGE 2024-11-08 Conference Coverage Seeking ways to improve the safety of anti-amyloid antibodies, John Sims of Eli Lilly & Company presented a simple option to do so for donanemab  at this year’s Clinical Trials on Alzheimer’s Disease conference, held October 29-Nov

NINDS Ruth L. Kirschstein National Research Service Award (NRSA) for Training of Postdoctoral Fellows (F32 Clinical Trial Not Allowed) (PAR-25-234)

GRANT Friday, November 8, 2024- 2:45pm National Institute of Neurological Disorders and Stroke Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-25-234.html 08 Jan 2028

Research Opportunities for New and "At-Risk" Investigators to Promote Workforce Diversity (R01 Clinical Trial Optional) (PAS-25-190)

GRANT Friday, November 8, 2024- 2:45pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAS-25-190.html 06 Nov 2027

Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Neurotherapeutic Agent Characterization and In vivo Efficacy Studies (R61/R33 Clinical Trial Not Allowed) (PAR-25-225)

GRANT Friday, November 8, 2024- 2:30pm National Institute of Neurological Disorders and Stroke Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-25-225.html 21 Oct 2027

Engineering Next-Generation Human Nervous System Microphysiological Systems (R01 Clinical Trials Not Allowed) (PAR-25-198)

GRANT Friday, November 8, 2024- 2:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-25-198.html 08 Jan 2026

Engineering Next-Generation Human Nervous System Microphysiological Systems (R21 Clinical Trials Not Allowed) (PAR-25-199)

GRANT Friday, November 8, 2024- 2:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-25-199.html 08 Jan 2026

Research Infrastructure Development for Interdisciplinary Aging Studies (R61/R33- Clinical Trial Optional) (PAR-25-218)

GRANT Friday, November 8, 2024- 2:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-25-218.html 03 Dec 2025

Advanced-Stage Development and Utilization of Research Infrastructure for Interdisciplinary Aging Studies (R33 Clinical Trial Optional) (PAR-25-219)

GRANT Friday, November 8, 2024- 2:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-25-219.html 03 Dec 2025

NIA Multi-site Clinical Trial Implementation Grant (R01 Clinical Trial Required) (PAR-25-222)

GRANT Friday, November 8, 2024- 2:15pm National Institute on Aging Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-25-222.html 08 Jan 2026

Bioengineering Partnerships with Industry (U01 Clinical Trial Optional) (PAR-24-325)

GRANT Friday, November 8, 2024- 2:00pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-24-325.html 08 Sep 2027

Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (R01 Clinical Trial Optional) (PAR-25-036)

GRANT Friday, November 8, 2024- 2:00pm National Institute of Mental Health, National Institute on Aging Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-25-036.html 08 May 2026

Trontinemab Data Strengthen Hope for Brain Shuttles

CONFERENCE COVERAGE 2024-11-08 Conference Coverage Fewer than 1 percent of amyloid-targeted monoclonal antibodies like lecanemab and donanemab reach their targets in the brain. The excess doses required to make up for this problem raise the risk of hazardous brain bleeding, reflected i

Notice of Pre-Application and Technical Assistance Webinar for RFA-MH-26-100, "BRAIN Initiative: Brain Behavior Quantification and Synchronization (R61/R33 Clinical Trial Optional)" (NOT-MH-25-060)

GRANT Friday, November 8, 2024- 1:45pm National Institute of Mental Health November 20, 2024. 2:00 PM- 3:00 PM Eastern Time. https://grants.nih.gov/grants/guide/notice-files/NOT-MH-25-060.html 21 Nov 2024