BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed) (RFA-NS-25-018)

GRANT Friday, September 27, 2024- 3:30pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-25-018.html 21 Jan 2026

Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access (U01 Clinical Trial Required) (RFA-NS-25-024)

GRANT Friday, September 27, 2024- 3:30pm National Institute of Neurological Disorders and Stroke Application due January 24, 2025. Letter of intent due 30 days prior to application. https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-25-024.html 25 Jan 2025

Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development of Disorders of the Nervous System (UG3/UH3 Clinical Trial Optional) (PAR-25-051)

GRANT Friday, September 27, 2024- 3:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/pa-files/PAR-25-051.html 19 Aug 2026

BRAIN Initiative: Reagent Resources for Brain Cell Type-Specific Access to Broaden Distribution of Enabling Technologies for Neuroscience (U24 Clinical Trial Not Allowed) (RFA-MH-26-120)

GRANT Friday, September 27, 2024- 3:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-26-120.html 16 Jun 2027

BRAIN Initiative: Optimization of Instrumentation and Device Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed) (RFA-NS-25-017)

GRANT Friday, September 27, 2024- 3:15pm National Institutes of Health Multiple due dates; see announcement. https://grants.nih.gov/grants/guide/rfa-files/RFA-NS-25-017.html 21 Jan 2026

PAPER Donnelly ML, Luke G, Mehrotra A, Li X, Hughes LE, Gani D, Ryan MD

Analysis of the aphthovirus 2A/2B polyprotein 'cleavage' mechanism indicates not a proteolytic reaction, but a novel translational effect: a putative ribosomal 'skip'.

J Gen Virol. 2001 May;82(Pt 5):1013-1025. PubMed.

CSF Proteins Spot Alzheimer’s Mutation Carriers Decades Before Symptoms

RESEARCH NEWS 2024-09-27 Research News Long before carriers of autosomal-dominant AD mutations notice the first hints of memory loss, changes in their brains are well underway at the protein level. In a study published September 26 in Cell, scientists led by Carlos Cruchaga at Wa

New Alzheimer’s Gene? Cytochrome P450 Protein Linked to Tangles

RESEARCH NEWS 2024-09-27 Research News To boost the statistical power to find Alzheimer’s genes, geneticists often use endophenotypes—measurable characteristics of the disease—in place of clinical diagnoses. Case in point: A genome-wide association study on more than 3,000 tau PE

Cell Symposia- Neuro-immune Axis: Charting the Periphery

CONFERENCE 2025-09-07 00:00:00-2025-09-09 00:00:00 New York City, New York 07 &#x2013 09 September 2025 View Conference Website 0

Cell Symposia: Neurometabolism in Health and Disease

CONFERENCE 2025-04-06 00:00:00-2025-04-08 00:00:00 Shenzhen, China 06 &#x2013 08 April 2025 View Conference Website 0

Therapeutic Approaches to Protein Misfolding in Neurodegenerative Disease

CONFERENCE 2025-04-28 00:00:00-2025-04-29 00:00:00 New York City, New York and Online 28 &#x2013 29 April 2025 View Conference Website 0

PAPER Yang L, Yang G, Guo H

First patient diagnosed with lipoprotein glomerulopathy and Alport syndrome.

Nephrology (Carlton). 2024 Sep 27; PubMed.

Synaptic Skirmish: Aβ and Tau Pathologies Battle Over Brain Rhythms

RESEARCH NEWS 2024-09-27 Research News When Aβ aggregates stoke synaptic fires, tau tangles put them out. This phenomenon, demonstrated in animal models, now gains support in a human study, published September 18 in Nature Neuroscience. Led by Sylvain Baillet at McGill University

PAPER Lee E, Lee Y, Yang S, Gong EJ, Kim J, Ha NC, Jo DG, Mattson MP, Lee J

Akt-activated GSK3β inhibitory peptide effectively blocks tau hyperphosphorylation.

Arch Pharm Res. 2024 Sep 26; PubMed.

PAPER Graham F

Daily Briefing: Drugs like Ozempic seem to help everything from Alzheimer's to infertility. But how?

Nature. 2024 Sep 25; PubMed.