Targeting Tumor Necrosis Factor—A Therapeutic Strategy for AD

• 2 Comments

29 May 2008

affected the clinical status of patients with moderate to severe heart failure (18-20). Etanercept (Enbrel)

Intraneuronal Aβ: Was It APP All Along?

20 Jun 2011

peptides, induces neuronal apoptosis. J Biol Chem. 2002 May 3;277(18):15666-70. Abstract Leon WC, Canneva F,

BDNF and Alzheimer's Disease—What's the Connection?

25 Nov 2003

15;18(18):7336-50. Abstract Patterson SL, Abel T, Deuel TA, Martin KC, Rose JC, Kandel ER. Recombinant BDNF rescues

The Neuroplasticity Theory of Alzheimer's Disease

• 1 Comment

08 Apr 2002

J. Wesson Ashford led this live discussion on 8 April 2002. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held Tuesday, 8 April 2002 Participants: John Wesson Ashford (W

Cell Cycle Hypothesis Pedaling into Mainstream Acceptance? Results in Fly, Mouse Models Warrant a Second Look

• 4 Comments

12 Apr 2006

Vikram Khurana, Karl Herrup, Bruce Lamb, Inez Vincent, Rachael Neve, Donna McPhie, Dan Geschwind, Cathy Andorfer, and Xiongwei Zhu participated in a discussion of how far the cell cycle hypothesis has come in the past few years, and where to go next. Vik

Gain or Loss of Function—Time to Shake up Assumptions on γ-Secretase in Alzheimer Disease?

• 23 Comments

25 Mar 2006

We invite you to participate in this “offline” Forum discussion with past ARF advisors Peter Davies of Albert Einstein College of Medicine in the Bronx, New York, and Bart De Strooper at K.U. Leuven, Belgium. The goal of this discussion is to explore the

Presenilin Loss of Function—Plan B for AD?

• 21 Comments

09 Mar 2007

These are comfortable times for the amyloid hypothesis, it would seem. Every week brings more good news about some anti-amyloid intervention having “cured” mice from their “Alzheimer’s.” On the human front, we are eagerly awaiting such therapeutics to sho

Cell Death: Time to Push It Out of the Doldrums

• 10 Comments

10 Sep 2004

poly ADP ribosyl polymerase-1 in acute but not chronic zinc toxicity. Eur J Neurosci. 18

Reimagining Alzheimer's Disease—Time for Bright New Ideas?

• 9 Comments

03 May 2011

Alois Alzheimer made a major breakthrough when he discovered senile plaques in the brains of dementia patients, and his work ultimately led to the discovery of amyloid-β and to the amyloid cascade hypothesis. But that cascade is only part of a much bigger

In Search of γ-Secretase

• 5 Comments

05 May 1999

Peter Nelson, with Dennis Selkoe, John Hardy, and Alain Israel, led this live discussion on 5 May 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion with Dennis Selkoe,

Protein Folding and Neurodegeneration: Biophysics to the Rescue?

30 Apr 2003

molecule as a recent (Apr 18) Science paper mentions and the article by Charlie Glabe of 1994

Cast Call for Players: Healthy Aging Through Lean Living

17 Aug 2004

unpublished data where rats exposed to six months of leuprolide (a suppressor of leutinizing hormone) lived 18

Calcium Signaling Deficit in the Origin of Alzheimer's Disease

• 8 Comments

07 Sep 2001

Live discussion and panel of participants scheduled for 7 September 2001.     Summary: "Ca2+ deficit" hypothesis Summary: "Natural origin" hypothesis for plaques and tangles The live chat and panel of participants scheduled for 7 Septe

Memantine: Implications for Treating Alzheimer's

29 Sep 2004

18 months, I believe (personal communication).     Dr. Kevin Foley How does a busy doctor in primary

Neural Stem Cells to the Rescue—Can Neuroreplacement Ever Become a Treatment for Alzheimer's?

09 Jul 2002

and recovery of cognitive function, Behavioral and Brain Sciences, 18 (1995) 10-35. 0 Tuesday, July 9,