346011 RESULTS
COMMENT Yes, at least some consensus would be appreciated, especially for people new to this field. For example, at the recent Neuroscience meeting in New Orleans, people were hedging on the latter case (presenilin-1 or γ-secretase?) even to the extent of questio
COMMENT There is nothing that upsets me faster than scientists using inappropriate and imprecise terminology and nomenclature. With respect to the Alzheimer's disease lexicon, the WHO and the International Nomenclature Committee on Amyloidosis have ALREADY d
CONFERENCE COVERAGE 2000-11-17 Conference Coverage Last year, Brad Hyman’s group reported on their ability to image amyloid plaques in the brains of live PDAPP Tg mice. Plaques could be detected as deep as 200 microns and the same plaques could be imaged over the course of weeks using
CONFERENCE COVERAGE 2000-11-17 Conference Coverage Several presentations focused on the role of presenilins in calcium signaling pathways. Leissring and LaFerla (Abstract 474.7) reported that cells from mutant PS1 knockin mice are deficient in capacitative calcium entry (i.e., the infl
CONFERENCE COVERAGE 2000-11-15 Conference Coverage What is the latest on the immunization of mice and men with Aβ? Will we be celebrating victory over Alzheimer’s disease in a few years (and looking for new jobs), or has the story been overrated? One would predict to see a number of po
CONFERENCE COVERAGE 2000-11-15 Conference Coverage CD40 is a member of the TNF receptor superfamily, which includes TNFR-1, TNFR-2, Fas, CD27, RANK, DR4 (TRAIL-R1), DR5 (TRAIL-R2), and DR6, as well as assorted decoy receptors (e.g., DcR-1/TRAIL-3). The TNF receptor superfamily is chara
CONFERENCE COVERAGE 2000-11-15 Conference Coverage A current working hypothesis in the field of AD research is that preventing the accumulation of Aß peptides will slow or prevent cognitive decline. Two main strategies for accomplishing this goal have been pursued in recent years. The
CONFERENCE COVERAGE 2000-11-14 Conference Coverage One of the most daunting tasks facing attendees of this gigantic neuroscience data exchange (dare I say "flea market"?) is identifying signals in the noise (speaking both scientifically and literally). One approach is to sit
RESEARCH NEWS 2000-11-13 Research News In today's Journal of Cell Biology, researchers of the University of Maryland Biotechnology Institute (UMBI) report that a molecule called ubiquilin regulates levels of presenilins, and is "highly expressed" in human neurons a
CONFERENCE COVERAGE 2000-11-10 Conference Coverage What do ßamyloid, buckyballs, and dark matter have in common? They were all mentioned in an intriguing presentation by Dr. Westlind-Danielsson (AstraZeneca, Abstract 299.2) on the formation of spheroidal "supramolecular structures
CONFERENCE COVERAGE 2000-11-10 Conference Coverage Being both an active scientist and a part-time reporter leads to some interesting situations. Most of the time, my scientific background could be considered an advantage when evaluating reports because I should have a better understand
CONFERENCE COVERAGE 2000-11-09 Conference Coverage It has previously been reported that the nerve growth factor (NGF) receptor trkA is depleted within the nucleus basalis, which is selectively damaged in early Alzheimer's disease. In a study presented this past Tuesday in a poster
CONFERENCE COVERAGE 2000-11-09 Conference Coverage It's a poorly kept secret that Aβ peptides are highly inconsistent in their neurotoxic properties. One batch of synthetic peptide will kill neurons handily, while another will be benign. Sarah Wright and her colleagues at Elan Pha
CONFERENCE COVERAGE 2000-11-09 Conference Coverage One of the earliest clues that apoE may contribute to AD pathology was the immunohistochemical demonstration by Namba and colleagues that ApoE was present in both plaques and tangles. ApoE did not really get serious consideration as a
CONFERENCE COVERAGE 2000-11-09 Conference Coverage The award for most aesthetically pleasing presentation almost certainly could go to Dr. Paul Thompson, who reviewed recent advances being made by a UCLA team in developing AD-specific brain atlases for assessing alterations in the brai
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