345829 RESULTS
RESEARCH NEWS 1999-10-22 Research News It is likely that a process very reminiscent of that suggested for Aβ formation-fibrillar protein deposition-is to blame for the rare, inherited disorder Familial British Dementia (FBD), according to a report in the most recent Nature Neuros
RESEARCH NEWS 1999-10-21 Research News According to a report in tomorrow's Science, researchers have uncovered a strong candidate for β-secretase, the mystery enzyme that cleaves APP and allows Aβ to be formed in subsequent cleavages. Martin Cintron, Robert Vassar, Brian Ben
COMMENT In the news article cited above, two important facts need clarification. First, protofibrils are fibrillar. Second, the first demonstration that protofibrils were neurotoxic was published by my group, in collaboration with Drs. Hartley, Selkoe, and others
RESEARCH NEWS 1999-10-15 Research News From today's Journal of Neuroscience comes evidence that intermediate Aβ species could be damaging neurons. Dean Hartley, Dennis Selkoe, and their colleagues report that so-called "protofibrillar" Aβ (oligomers intermediate be
RESEARCH NEWS 1999-10-12 Research News Further evidence that ApoE is needed for deposition of the fibrillar form of Aβ in plaques was presented today at the American Neurological Association's annual meeting in Seattle today. David Holtzman and his colleagues at Washington U
RESEARCH NEWS 1999-09-22 Research News Protein misprocessing and aggregation have been observed in many neurodegenerative diseases, including Alzheimer’s, spongiform encephalopathies, Huntington’s, Parkinson’s and FTDP-17, but it has been difficult to untangle the causal relation
RESEARCH NEWS 1999-09-22 Research News Writing in the current Nature Neuroscience, Heather Cameron and Ronald D.G. McKay report that they were able to boost the rate of neurogenesis in the hippocampus of aging rats by lowering corticosteroid levels. The results support the hypoth
RESEARCH NEWS 1999-09-15 Research News In today's Journal of Neuroscience, Vivian Budnik, Laura Torroja, and their colleagues at the University of Massachusetts, Amherst, and Brandeis University, Massachusetts, provide evidence that under normal circumstances, APP is a criti
RESEARCH NEWS 1999-09-13 Research News In the current Nature Cell Biology, Susan Lindquis and Jiang Ma of the Howard Hughes Institute at the University of Chicago report that they were able to produce abnormal prion protein (PrP) conformations from normal PrP, apparently by causi
RESEARCH NEWS 1999-08-31 Research News Douglas Smith and his colleagues at the University of Pennsylvania may have filled a gap in research on long-term, neurodegeneration sequelae of brain injuries by showing Aβ and tau production in an animal model of brain trauma. Their porcin
RESEARCH NEWS 1999-08-26 Research News If the inflammatory cytokine tumor necrosis factor α (TNF-α) is at work in Alzheimer's disease, it may not be relying on its well-described, directly apoptotic mechanism to cause problems, according to a report by Keith W. Kelley and hi
WEBINAR 1999-08-13 Chris Weihl, with Bruce Yankner, Benjamin Wolozin, Eddie Koo, and Kenneth Kosik led this live discussion on 13 August 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion
WEBINAR 1999-08-03 June Kinoshita, with Peter Davies, led this live discussion on 3 August 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Paper under discussion: Lu, Pei-Jung, Wulf, Gerburg, Zhou, Xiao Zhen, D
RESEARCH NEWS 1999-07-29 Research News In the August issue of Nature Neuroscience, Bruce Lamb and his associates at Case Western report that they have transferred complete copies of genes for mutant human APP and PS-1 into mice that subsequently produce high levels of Aβ and even
RESEARCH NEWS 1999-07-28 Research News Various recent studies have reported a link between head trauma and and an increased risk of Alzheimer's disease, but why this might be has been a matter of speculation. In this month’s Journal of Neurochemistry, Tracy McIntosh, Michell
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