345779 RESULTS
RESEARCH NEWS 2000-03-01 Research News For more than a decade, a case has been building for the involvement of inflammatory processes in the pathogenesis of Alzheimer's disease. Now researchers say they have found definitive evidence that implicates the inflammatory cytokine
RESEARCH NEWS 2000-03-01 Research News A team led by Thomas Meade at the California Institute of Technology has developed an MRI contrast agent that is activated only in the presence of a target gene, according to a report in the March issue of Nature Biotechnology. Unlike conven
RESEARCH NEWS 2000-02-29 Research News Circumstantial evidence has accumulated over the last decade that there are pluripotent stem cells in the hippocampus of humans and other animals. Much hope has been attached to these heretofore elusive cells because they might be induced to
RESEARCH NEWS 2000-02-23 Research News The Ts65Dn mouse developed at the Jackson Laboratory in Bar Harbor, Maine, has the signature skull and facial deformities of Down's syndrome, strengthening its case as a model for the human syndrome, according to report at the recent AA
RESEARCH NEWS 2000-02-23 Research News Previous studies have shown that women who take estrogen reduce their risk of developing Alzheimer’s disease. But can estrogen also benefit women who already have been diagnosed with the disease? Apparently not, according to a study by a Uni
RESEARCH NEWS 2000-02-21 Research News Memory deficits due to NMDA receptor loss in the hippocampus can be overcome by enriched environments, according to a report from Joe Tsien and his Princeton colleagues in the March issue of Nature Neuroscience. Tsien and others had previous
RESEARCH NEWS 2000-02-17 Research News Several neurodegenerative diseases, including Alzheimer's, Parkinson's and Lewy body disease, are characterized by abnormal neuronal inclusions of α-synuclein, one of the brain's synaptic proteins. Suspicion that this protein
WEBINAR 2000-02-17 Dennis Selkoe, Dean Hartley, and William Klein led this live discussion on 17 February 2000. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Transcript: Live discussion held Thursday, 17 February 200
RESEARCH NEWS 2000-02-16 Research News One part of the answer to this question may involve the yeast nuclear protein Sir2, according to a study in tommorow's issue of Nature. Leonard Guarente, Shin-ichiro Imai, and their coworkers at MIT say the protein, which extends the li
RESEARCH NEWS 2000-02-16 Research News Genetic tests based on polymerase chain reactions often fail to detect mutations when both a mutant and a wildtype gene exist in the genome. The key to "unmasking" the mutant allele, according to the authors of a study in tommorow&
RESEARCH NEWS 2000-02-07 Research News A caspase protease in the endoplasmic reticulum (ER) may have a hand in cell death in Alzheimer's, according to a report in the January 6 issue of Nature. (Apologies for the delay in reporting this story!) The caspases, a family of cyst
RESEARCH NEWS 2000-01-27 Research News The essential "prion-determining" portion of a prion protein can be removed and fused to a wholly separate protein, creating a new prion with the essential prion qualities of state changing and heritability, report Susan Lindquist
RESEARCH NEWS 2000-01-24 Research News Some of the earliest cellular changes of the trinucleotide repeat disorder spinocerebellar ataxia type 1 (SCA1) appear only one day after the mutant gene that causes the disorder begins to be expressed. In a report in the February issue of N
RESEARCH NEWS 2000-01-21 Research News A transcript of Bio Online's panel discussion on January 12 is now available at http://www.bio.com/newsfeatures/newsfeatures_infocus.jhtml?InFocus=67389. James W. Geddes moderated the discussion with Mark E. Gurney, Ole Isacson, Jeffrey
RESEARCH NEWS 2000-01-11 Research News As with many neurodegenerative diseases, viruses have waxed and waned in popularity as possible causative agents in amyotrophic lateral sclerosis (ALS, known as Lou Gehrig's disease in the U.S.). A study in this month's issue of Ne
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