345779 RESULTS
RESEARCH NEWS 2000-05-05 Research News The neuronal peptide α-synuclein is an important constituent of the Lewy bodies, pathological hallmarks of the Lewy body variant of Alzheimer's disease, as well as of Parkinson's and several other neurodegenerative diseases. Beyond
INTERVIEWS 2000-04-26 Interviews ARF: What is the primary hypothesis that guides the research in your lab? BW: My laboratory's research is focuses on two different projects: presenilins (PS) and alpha-synuclein. With regard to presenilins the primary hypothesis that we ar
RESEARCH NEWS 2000-04-24 Research News Many researchers believe that the amyloid-β peptide is a culprit in the neurodegenerative process of Alzheimer's disease. Indeed, they can marshal good evidence that the fibrillar form of Aβ kills neurons in a petri dish. If this is ind
RESEARCH NEWS 2000-04-24 Research News Some of the attention focused on amyloid-β may have to be diverted to yet another peptide product of amyloid precursor protein (APP). Daniel Lu, Edward Koo and colleagues report in the April issue of Nature Medicine that the 31 amino-acid pe
RESEARCH NEWS 2000-04-13 Research News Inhibiting cell death proteases, or caspases, can prolong the life of mice with the fatal motor neuron disease amyotrophic lateral sclerosis (ALS), Robert Friedlander of Harvard Medical School and Brigham and Women’s Hospital, Boston, Massac
COMMENT This letter is in response to the recent article in Journal of Clinical Microbiology (38[2]:881-882, 2000) entitled "Failure to detect Chlamydia pneumoniae in brain sections of Alzheimer's Disease Patients" by Gieffers et al. Since we were
INTERVIEWS 2000-04-07 Interviews ARF: Outline for us what you think are the steps lead to AD pathogenesis? What role do beta amyloid and tau play in AD? Are they related or independent events? MM: Amyloid plaques (AP) and neurofibrillary tangles (NFT) are the two diagnostic ma
RESEARCH NEWS 2000-04-07 Research News Researchers from the Medical University of Lubeck in Germany say that they have failed to replicate the tantalizing evidence from a study published two years ago that found Chlamydia in almost all the Alzheimer's brains examined. The Ge
RESEARCH NEWS 2000-04-06 Research News Conventional wisdom has it that each member of the large G protein-coupled receptor (GPCR) family pairs up exclusively with another of its own kind. But a new study in tomorrow's Science reports that two different GPCRs, mediating the a
COMMENT The study shows that both the 40 and 42 amino acid amyloid peptides were elevated early in Alzheimer's disease and that levels of both peptides are strongly correlated with cognitive decline. These are novel and important observations. However, as wi
COMMENT This is an interesting study that does, indeed, push ahead in some ways the type of correlational studies that have been going on for years. The power of the study is the large number of subjects and the use of ELISA technology to quantitate Aß. There has
RESEARCH NEWS 2000-04-05 Research News A central controversy in the Alzheimer's field has been the issue of whether amyloid plaques, comprising primarily Aβ peptide, correlate with the severity of dementia. Inconsistent findings on this point have fueled arguments over the r
RESEARCH NEWS 2000-03-22 Research News Mel Feany and Welcome Bender of Harvard Medical School have succeeded in creating a transgenic Drosophila melanogaster model of Parkinson's, and surprisingly, have demonstrated that the flies feature all the hallmarks of the human disea
RESEARCH NEWS 2000-03-10 Research News Kazemi-Esfarjani and Benzer of California Institute of Technology report in today's Science the discovery of two genes that protect against eye degeneration resulting from aggregation of polyglutamines in Drosophila. Polyglutamine toxic
RESEARCH NEWS 2000-03-07 Research News Insulin-degrading enzyme (IDE) plays a role in breaking down Aβ outside of neurons, report Dennis Selkoe, Konstantinos Vekrellis, and their colleagues at Harvard in the March 1 issue of the Journal of Neuroscience. The finding highlights gro
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