345539 RESULTS
RESEARCH NEWS 2001-04-12 Research News Researchers from France reported success in synthesizing novel compounds that specifically target γ-secretase cleavage of amyloid-β (Aβ) peptide, without affecting the enzyme's cleavage of other substrates such as Notch and possibly Ire
RESEARCH NEWS 2001-04-02 Research News Immune Network Ltd. reported last week that the company's Canadian Phase I clinical study has been halted due to an unexplained incidence of adverse findings in blood samples from healthy volunteers. Studies are now under way to investi
RESEARCH NEWS 2001-03-30 Research News (From Nature press release). Stem cells from mouse bone marrow can help repair muscle killed in heart attacks, Piero Anversa and his team at New York Medical College, New York, and colleagues, show in [the 5 April issue of] Nature. The resul
COMMUNITY NEWS 2001-03-27 Community News A team at Dartmouth College, New Hampshire, has developed a brain-image repository that will make it possible for scientists to freely share fMRI data with colleagues worldwide. The National Functional Magnetic Resonance Imaging (fMRI) Data
INTERVIEWS 2001-03-23 Interviews ARF: What is the hypothesis driving research in your lab? SG: We are investigating the role of signal transduction in regulating b amyloid generation; both the possibility (1) that changes in signalling contribute to disease-related changes in
RESEARCH NEWS 2001-03-22 Research News The abnormal form of the protein huntingtin may exert its toxic effects on neurons in Huntington's disease by interfering with a protein essential for gene transcription, according to a study published in this week's issue of Scien
RESEARCH NEWS 2001-03-15 Research News (From Nature press release.) It is now generally accepted that new neurons are generated in the adult mammalian brain, but until now it has been unclear whether or not these neurons are essential for memory formation. This week [in Nature],
RESEARCH NEWS 2001-03-15 Research News (From Science press release.) A British and German team has made the surprising discovery that the cell's mitochondria can export peptides into their surrounding environments [reported in tomorrow's issue of Science]. Much is known
RESEARCH NEWS 2001-03-09 Research News [From Nature press release] Understanding the mechanisms regulating brain wiring has until now relied on biochemical purification approaches in vertebrates and genetic approaches in invertebrates to identify molecular clues. This week Marc T
RESEARCH NEWS 2001-03-09 Research News [From Nature press release.] This week Peter Chien and Jonathan Weissman of the University of California, San Francisco, explain how they used two species of yeast (Candida albicans and Saccharomyces cerevisae) and an artificial yeast prion
RESEARCH NEWS 2001-03-07 Research News Aggregated proteins, or amyloids, are seen in a wide variety of neurodegenerative diseases, including Alzheimer's and Creutzfeldt-Jakob (CJD) disease. Such aggregates are generally considered to be aberrant formations, but a new study s
COMMUNITY NEWS 2001-03-05 Community News On February 28, 2001, the U.S. Food and Drug Administration (FDA) approved Reminyl® (galantamine hydrobromide) for the treatment of mild to moderate Alzheimer's disease. Data from placebo-controlled, double-blind clinical trials involv
RESEARCH NEWS 2001-02-27 Research News The most promising target for an Alzheimer's therapy in the short term may be the enzyme β-secretase, suggest two papers in the March issue of Nature Neuroscience. Two separate groups have found that mice lacking the BACE1 isoform of β-
RESEARCH NEWS 2001-02-26 Research News Deleting a critical gene for iron metabolism leads to selective neurodegeneration, according to a study in this month's Nature Genetics. When researchers, led by Tracey Rouault and Timothy La Vaute of the U.S. National Institute of Chil
COMMENT Question: Are Alzheimer's Disease and "Senile Dementia" the Same Disease? This perhaps is the most important "nomenclature" problem. AD used to refer to "pre-senile" dementia (PSD; middle age dementia). This name clearly
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