344037 RESULTS
CONFERENCE COVERAGE 1998-11-11 Conference Coverage The organizers of this year's special interest social on Alzheimer's disease decided to stage an awards ceremony to salute scientists who had distinguished themselves in various categories not ordinarily recognized by the com
CONFERENCE COVERAGE 1998-11-10 Conference Coverage The complement cascade is a complex inflammatory process that can mediate diverse functions, from targeting cells and cellular components for phagocytosis to membrane attack complex-mediated cell death. In this context, there are 20 or
CONFERENCE COVERAGE 1998-11-10 Conference Coverage Aβ peptide has dominated center stage in AD research, but the discovery last year of a tau mutation that causes a familial non-AD dementia has reawakened broader interest in tau. In Alzheimer’s disease, tau aggregates into pathological
CONFERENCE COVERAGE 1998-11-08 Conference Coverage Are both Aβ and the intracellular hyperphosphorylation of tau necessary for the induction of morphological alterations in dendrites in AD? What effect might abnormally shaped dendrites have on synaptic transmission? Using triple labeli
CONFERENCE COVERAGE 1998-11-08 Conference Coverage Fred van Leeuwen and his research group presented new data regarding their molecular misreading hypothesis for sporadic AD (Abstract 107.7). The molecular misreading hypothesis suggests that the inaccurate conversion of genomic informa
CONFERENCE COVERAGE 1998-11-08 Conference Coverage Hopefully, transgenic AD models will be more useful than just demonstrating that the overexpression of mutant human APP can lead to the deposition of Aβ plaques. Several groups are now asking, what are the functional consequences of th
CONFERENCE COVERAGE 1998-11-07 Conference Coverage Presented by Rudy Tanzi. AD is now widely considered to be a multifactorial disease with only a few dominant genetic mutations that can be considered as directly causing the disease, i.e., APP and the presenilins. The majority of genet
RESEARCH NEWS 1998-11-05 Research News It is known that aspirin and sodium salicylate suppress inflammation by inhibiting cyclooxygenase, an enzyme that triggers production of prostaglandin. It has been suspected that these compounds also exert their anti-inflammatory effects thr
RESEARCH NEWS 1998-10-30 Research News It has long been a dogma of neuroscience that the human brain is born with all the neurons it will ever have, and that those neurons must endure for a lifetime. But evidence has been accumulating that this dogma may not strictly be true. Neu
RESEARCH NEWS 1998-10-30 Research News The idea of treating developmental and neurodegenerative disorders by growing new brain cells has taken a major step forward, according to results of two studies appearing in the November issue of Nature Biotechnology. Evan Snyder and collea
RESEARCH NEWS 1998-10-22 Research News Can transgenic mice serve as a truly useful model for studying Alzheimer's disease? Studies of mice expressing an APP gene mutation that causes a form of familial AD have reported no neuronal loss, despite the presence of amyloid plaque
RESEARCH NEWS 1998-10-15 Research News Since the discovery that mutations in the gene for PS1 cause familial Alzheimer's disease, there has been keen interest in investigating the mechanism by which PS1 mutations cause disease. It has been shown that PS1 associates with memb
RESEARCH NEWS 1998-10-14 Research News A study published in last month's Neurology reports that professional soccer players are at significantly higher risk for long-term brain injuries that affect their mental function. These brain injuries result from either heading the ba
RESEARCH NEWS 1998-10-14 Research News A diet rich in certain fruits and vegetables is known to protect against cancer and heart disease, and now a new animal study in the October Journal of Neuroscience suggests nutrition can also stall the decline of brain function that comes w
RESEARCH NEWS 1998-10-13 Research News Estrogen has been shown in recent years to be a possible protective factor in Alzheimer disease, and now new studies suggest it may also protect against the risk of Parkinson's disease. Preliminary data from four studies were presented
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