344037 RESULTS
CONFERENCE COVERAGE 1998-12-12 Conference Coverage Harada et al. (Abstract 902) have now disrupted the MAP2 gene in mouse. Like tau and MAP1B knockout mice, MAP-2 knockout mice are fertile and have apparently normal brain cytoarchitecture. Interestingly, double tau and MAP1B knockout m
CONFERENCE COVERAGE 1998-12-12 Conference Coverage Chan et al. (Abstract 1421) used immunoblot analysis to quantitatively demonstrate that the polypeptides corresponding to AMPA (GluR2 and 3) and NMDA subfamilies of the glutamate receptors are decreased in AD brain lysates compared to
CONFERENCE COVERAGE 1998-12-12 Conference Coverage Mervyn Monteiro (the author of this report) and colleagues described the identification and characterization of two different proteins that interact with presenilins in the yeast-2 hybrid interaction trap (Y2H). Stabler et al. (Abstrac
CONFERENCE COVERAGE 1998-12-12 Conference Coverage Monteiro and Janicki et al. (Abstract 1057) showed by BrdU labeling of HeLa cells that overexpression of both PS1 and PS2 arrest cells in the G1 phase of the cell cycle. This arrest presumably precedes apoptosis of the cells which this
INTERVIEWS 1998-12-10 Interviews During his medical school training in neurology at Harvard, Bruce Yankner was drawn into the Alzheimer field when he found that an APP gene construct (C100) was toxic to neurons. "Alzheimer's disease was one of few neurodegenerative d
RESEARCH NEWS 1998-12-08 Research News Mutations in the β-amyloid precursor protein (APP), presenilin-1 and presenilin-2 cause inherited forms of Alzheimer's disease, but how do these protein interact, normally and in the disease process? In 1996, researchers Nazneen Dewji a
RESEARCH NEWS 1998-12-04 Research News A new study elucidates the molecular mechanisms that may explain how mutations of the tau gene give rise to frontotemporal dementia and parkinsonism (FTDP-17), an inherited disorder that is similar to Alzheimer's disease. In this week&#
CONFERENCE COVERAGE SERIES News Coverage of the 4th Hungarian Conference on AD: Hungarian Conference on Alzheimer's Disease and Related Disorders 1998
RESEARCH NEWS 1998-12-01 Research News (From Nature Biotechnology Press Release.) Current estimates predict that genome sequencing efforts may reveal between 3,000 and 10,000 new targets for drugs. In the December issue of Nature Biotechnology, Paul Negulescu and colleagues descr
CONFERENCE COVERAGE 1998-12-01 Conference Coverage Introduction: This annual meeting had significant international participation with 14 different countries being represented and, whilst comprehensive, the meeting focused on the cholinergic system, therapeutics and new findings. The op
CONFERENCE COVERAGE 1998-11-12 Conference Coverage The critical role of ApoE in β-amyloid deposition was demonstrated last year by Eli Lilly scientists, who crossbred APP/PS1 transgenics with an ApoE knockout and found that these mice do not develop thioflavin S-positive deposits of fi
CONFERENCE COVERAGE 1998-11-11 Conference Coverage The regulation of neuronal plasticity and regeneration in the CNS is an aspect of Alzheimer’s disease that often has to compete with the big stars, such as amyloid or presenilin, for attention. Yet, it is clear that understanding the f
CONFERENCE COVERAGE 1998-11-11 Conference Coverage Since the development of transgenic models of β-amyloid plaque formation, considerable debate has developed over the apparent paucity of neuronal cell loss found in the majority of these models. One hypothesis for why there is an overa
CONFERENCE COVERAGE 1998-11-11 Conference Coverage There have been several reports over the years that the AD brain exhibits deficits in energy metabolism. In 1994, Yankner's group reported that sodium azide treatment increased the processing of APP to potentially amyloidogenic fr
CONFERENCE COVERAGE 1998-11-11 Conference Coverage The Athena Neuroscience PDAPP transgenic mice develop heavy Aβ deposits, particularly in the outer molecular layer (OML) of the dentate gyrus, a region that receives nerve projections from the entorhinal cortex. Theorizing that neurona
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