Lary Walker on Aiding and Abetting, Hyperactive CDK5 Gives Mouse Tangles

COMMENT Neurofibrillary tangles consist of tau protein that has forsaken its role as a stabilizer of microtubules to polymerize into abnormal fibrils within neurons. Preclinical and clinical evidence leaves little doubt that abnormal tau polymerization is injurio

Lary Walker on Aβ, Shifty Drifter? Tissue Grafting Sheds Light on Plaque Formation

COMMENT These elegant experiments by Meyer-Luehmann and colleagues demonstrate that the proteopathic corruption of tissue can be more strongly influenced by the environment in which the tissue develops than by the lineage of the tissue itself (I will forego the o

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