Lars Lannfelt, Dag Sehlin, Hanna Laudon, Linda Söderberg on Sweat the Small Stuff: Teeniest Aβ Oligomers Wreak Most Havoc

COMMENT The experience from genetic findings in the early 1990s strongly point to Aβ as the culprit in Alzheimer’s disease. However, we still do not understand how Aβ confers cognitive dysfunctions and neuronal atrophy. For several years we have witnessed an incr

Olof Zachrisson, Hans Basun, Lars Lannfelt, Christer Nordstedt on In Familial AD, Amyloid-PET Varies by Mutation Type; CSF Aβ42 Doesn't

COMMENT This highly interesting paper reports that, in autosomal-dominant AD, the 11 C-Pittsburgh compound B (PiB)-PET signal displayed mutation-dependent variability, despite similar progression on the clinical dementia rating. Although pathogenic variants causi

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