Gary Landreth on Liver X receptor agonist treatment ameliorates amyloid pathology and memory deficits caused by high-fat diet in APP23 mice.

COMMENT The role of diet, and particularly dietary cholesterol, on AD risk and pathogenesis is of substantial interest and importance. The recent paper from the Lefterov and Koldamova lab that appears in the current issue of the Journal of Neuroscience sheds cons

Gary Landreth on Statins Boost α-Secretase, but Not Through Cholesterol

COMMENT Clincial evidence suggests that long- term use of statins is associated with a decreased risk of Alzheimer disease (AD). As these drugs block the synthesis of cholesterol, much research has been focused on the importance of cholesterol metabolism in the p

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