41 RESULTS
COMMENT Arguing about whether it is Aβ40, Aβ42 or not is missing the important point: It is aggregated in an amyloid-like fashion, because it reacts with a large number of antibodies that only react with aggregated or fibrillar conformations. If it is aggregated
COMMENT This is an interesting paper that underscores the conformational polymorphisms in β-sheet aggregates of Aβ. This one is unique in two aspects: It is the first structure that is a triple parallel, in-register sheet, and it is unique to Aβ42. I’m not sure h
COMMENT Cell models for prion infection, replication, and strain behavior have long been available to prion researchers. These include stable lines producing transmissible prion aggregates and inducible cell lines that are dependent on the addition of exogenous p
COMMENT Cognitive deficit is not a side effect of Alzheimer's disease treatment. It is the primary manifestation of disease. The simplest explanation is that you are thinking about the mechanistic relationship between Aβ secretion and pathogenesis backwards.
COMMENT This is an interesting paper that reports that Aβ17-40 (also known as P3) forms β-sheet amyloid fibrils with properties like that of its longer sibling, Aβ1-40. Aβ variants at the carboxyl terminus and amino terminus have been extensively investigated whi
COMMENT This paper by Huang et al. reports a number of interesting observations that provide significant insights into the role of microglia in Alzheimer’s disease and into the mechanism of plaque biogenesis that have a number of implications for the amyloid hypo
COMMENT This is an interesting and important study. The authors report the first structure of Aβ42 fibrils from the brain and although there have been other reports of Aβ42 fibril structures assembled from monomer in vitro, previous work has indicated that the st
COMMENT This interesting and exciting paper by Nixon and co-workers confirms and extends a model for neuritic plaque formation that we previously reported (see Fig 4 below from Pensalfini et al., 2014). We used a fibril-specific monoclonal antibody, mOC78, which
COMMENT I am a co-author on the Lesne Aβ*56 paper because we supplied one of the antibodies used, A11, with standards to authenticate it. Sadly, this was not the first or the last high-profile paper in our field that could not be replicated. I don’t think Aβ*56 h
COMMENT Reading this paper from the laboratories of Michel Goedert and Sjors Scheres at the MRC in Cambridge, U.K., is like opening a box of chocolates for the holidays and finding a delightful assortment of shapes and structures: treats as food for thought. I ha
COMMENT In this paper, the authors from the laboratory of Dag Sehlin, and coworkers, provide an interesting update on the properties of the Uppsala APP mutation in transgenic mice (Pagnon de la Vega, et al., 2024). A previous report described that the Uppsala mut
