23 RESULTS
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COMMENT The sensitivity and specificity of tau tracers for human tau pathology cannot be known until there have been a substantial number of imaged patients with autopsies and neuropathological diagnoses. Clinical diagnostic accuracy for non-Alzheimer's deme
COMMENT Multicenter studies with enforced blinding of results assessment will be necessary to resolve the discrepancies in reports from different labs. As mentioned in this paper, a very well respected Johns Hopkins group (Ho et al., 2013) found no evidence for e
COMMENT Readers should see comments made earlier this year on the same topic, i.e., my own comment regarding labs at Johns Hopkins and Massachussetts General Hospital that have not seen Aβ or tau pathology in the retina of AD subjects (see references below). Our
COMMENT The publication of Gibbons et al., like most clinical biomarker studies, suffers first and foremost from the use of an inadequate gold standard. The clinical diagnoses of Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy are all
COMMENT Agree that it is no longer correct to assume that white matter rarefaction is equivalent to or completely accounted for by small vessel disease. Our comprehensive postmortem study suggests that neuofibrillary tangles are statistically a much greater predi
COMMENT The announcement by the FDA of their Final Rule for increased oversight of laboratory developed tests (LDTs) is long overdue but very welcome. Once fully implemented, this should greatly increase the scientific rigor required for certifying LDTs for clini
COMMENT As usual for biomarker studies “validated” by the clinical diagnosis of PD, the “true” diagnostic accuracy cannot be claimed to be higher than the known clinical diagnostic accuracy against the postmortem diagnosis of PD. As these are all “de novo” PD cas
COMMENT This report is intriguing and reinforces the power of single-nucleus studies of human postmortem brain tissue for understanding neurodegenerative disease. The identification of RORB as a possibly critical protein associated with selective vulnerability ma
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