11505 RESULTS
COMMENT This news report does not mention that the serine protease at the centre of the urokinase-plasminogen activator system, namely plasmin, is selective for Aβ 42 and in cleaving Aβ 42 prevents its aggregation into β-pleated sheet structures (see Exley and Ko
COMMENT The compelling data by Mauch et al. affirms the critical nature of cholesterol in the CNS, particularly the developing CNS. As with most very good research, the experiments lead to important answers and provide the foundation for more questions. These aut
COMMENT Mauch et al., in a well-designed, interesting study, demonstrate the importance of cholesterol to the formation of electrically functional synapses in cultured retinal ganglion cells. They demonstrate that retinal ganglion cells attain their normal morpho
COMMENT I liked the paper very much. It is generally well done and suggests an easy intervention that could reduce AD onset or progression without significant toxicity. Among the questions it raises are: 1.) How does the concentration of curcumin that is effectiv
COMMENT Comment by Mark Gluck, Kin Ho Chan, M. Todd Allen Although these results are intriguing, the
COMMENT α-Synuclein and β-amyloid: A Linking of Partners to Model Disease Creating transgenic models of neurodegenerative disease has yielded mixed results. The transgenic models of Huntington's chorea and amyotrophic lateral sclerosis have yielded animal mo
COMMENT Reply to Dr. Wong by Ming Chen Many factors are required in brain function, but their roles are not EQUAL. Ca2+ is the only factor that is known today to be both NECESSARY and SUFFICIENT for triggering and controlling neurotransmitter release (any textboo
COMMENT The data in the paper by Sigurdsson et al. are convinced that the immunization protocol they used is effective in decreasing plaque burden in the Tg2576 (also called APPsw) mouse model of AD. They present nice evidence that the peptide with which they imm
COMMENT Clarification of the confusing terms such as Aβ, βA, APP, βAPP or AβPP will help the field if they can be standardized. But here, I would like to reiterate the key importance of another "nomenclature" problem, i.e., "Alzheimer's diseas
COMMENT This debate makes me rethink some basic issues in AD. Here I have another question. Calcium is important for brain function, no problem. But many other factors are also important such as aluminum, zinc, iron, acetylcholine, mitochondria, cAMP,or NO. Brain
COMMENT Reply to Dr. Wong by Ming Chen First, let me take this opportunity to thank Drs. Wong, Scatty and Aldoso for raising in-depth and sharp questions. In science, asking the right questions sometimes can be as important as solving them. The AD field today nee
COMMENT A very stimulating hypothesis. But, a problem is that it is all based on your findings in a single experimental paper suggesting that alpha-secretase may be a calpain. At the same time, however, there are over 50 or so proteases being also proposed today
COMMENT Reply to Dr. Aldoso by Ming Chen In the world of research, we develop hypotheses based on facts. But perhaps the most difficult job is to judge, among the numerous reports, which ones are facts and which are not. Many papers have reported that calcium ant
COMMENT To my knowledge, there are probably over a hundred of reports showing that calcium channel blockers have protective effects in old cells or animals and even in AD patients. So, whatever your theory is (though it is interesting), a rule is that one cannot
COMMENT Reply to Dr. Scatty by Ming Chen Conceptualization of Ca2+ signals in the brain as dynamic "spikes" (1-3), instead of traditionally perceived steady-state "level" changes, is essential to explain some key dilemmas that have severely ha
