11617 RESULTS
COMMENT Biology is at a wonderfully exciting, but vexing point. We have the sequences for all of the human genes. However, the business end of the body occurs [is run by] the products of the genes. Often, to understand how things are functioning, or what happens
COMMENT I fully agree with the previous comments. DJ-1 as the gene product of the PARK7 locus indeed
COMMENT A very interesting study, characterizing the mouse model for Parkinson's disease and underlining its potential as directly related to new findings in human PD patients. 0 fred.vanleuven
COMMENT This is a fascinating problem. Why should a mutation on one haplotypic background be recessive, but on others be dominant? 0 J.Hardy
COMMENT I think this is a wonderful discovery. It is going to open up new possibilities and opportunities for understanding the pathogenesis of PD. tdawson 0
COMMENT This paper provides the first compelling explanation for the regional selectivity in AD. These results well substantiate the hypothesis first put forth by Lambert et al. (PNAS, 1998) that Aβ 1-42 oligomers (ADDLs) are the causative amyloid toxins in AD. T
COMMENT Stem cells have the potential to treat and possibly cure a variety of disorders, particularly those of the central nervous system. To develop successful clinical therapies, the fate of these cells after grafting must be monitored in a noninvasive manner.
COMMENT to characterize the normal function of APP and Aβ at the synapse. The conclusion in a comment that
COMMENT Bonifati and colleagues bring genetic evidence of oxidative imbalance to the field of Parkinson’s disease research. In light of the abundant biochemical data demonstration nitration (Good et al., 1998; Giasson et al., 2002), lipid peroxidation and glycati
COMMENT This is potentially one of the most important findings in the Parkinson's disease field in recent years. What is particularly important is that the DJ-1 gene apparently encodes a protein involved in cellular resistance to oxidative stress, and that t
COMMENT Whenever a new gene for a major neurodegenerative disease is uncovered, it creates a blast of excitement and a flurry of lab activity. This paper is likely to have that effect, as it describes a new gene for autosomal recessive early onset Parkinsonism wi
COMMENT For further discussion please see: Neurobiol Lipids, Vol.1, 3 (2002) 0 postmaster
COMMENT The two studies demonstrate that if you interrupt the supply of APP to terminals in cortical brain circuits, you abort even existing amyloid deposits outside neurons. This shows that you need a constant supply of APP to maintain the plaques, or that struc
COMMENT This is an exciting study to show in vivo migration of stem cells in the brain. I talked with the author at the Neuroscience meeting in Orlando, and was immediately impressed with their results. It shows dynamic migration of transplanted stem cells toward
COMMENT Although statins may well be a godsend for patients with cardiovascular disease and perhaps Alzheimer's disease, the cholesterol management market is currently looking beyond statins. Why? One hard fact is that time is getting close for the expiratio
