11617 RESULTS
COMMENT Multiple studies suggest that statin treatment can lower Aβ production and might be beneficial in treating AD. Cell biology studies show that cells or animals treated with statins exhibit less Aβ production. Statins also lower Aβ levels in humans. Epidemi
COMMENT This study provides much food for thought and further investigation, though I think the interpretations of the results are a bit narrow. They are predicated on several debatable premises, for example, that the cholesterol pool in the brain is essentially
COMMENT This is an important contribution to the literature on the long-term associations of smoking. The strength of the study is in its careful examination of relevant exposures in mid-life, extended detailed follow-up with good response rates, and the inclusio
COMMENT This grading explains one important feature of Alzheimer's disease, namely the formation of senile plaques: they appear precisely with the arrival of tau pathology in a given area. Senile plaques are in fact a marker of recently affected brain areas
COMMENT These findings represent an intriguing potential convergence with our own data (see ARF related news story), which demonstrated that parkin forms a ubiquitin ligase complex that downregulates cyclin E. Cyclin E has been shown to accumulate in some mammary
COMMENT Maria Eriksson, Gabrielle Strobel, and Ann Pluta for critical comments and suggestions. I apologize for
COMMENT Maria Eriksson, Gabrielle Strobel, and Ann Pluta for critical comments and suggestions. I apologize for
COMMENT The article by Anderson and colleagues elegantly combines genetic and pharmacological approaches to argue for a primary role of iron in Parkinson's neurodegeneration in vivo. The authors suggest that chelators of iron abrogate cell death due to inhib
COMMENT This paper is very important. That statins reduce 24S-cholesterol was to be expected from previous studies. Indeed, the major future application of this work may grow out of its demonstration that AD patients respond within only six weeks to dosages of 40
COMMENT This paper demonstrates a much higher incidence of dementia in PD patients than previously reported. This might reflect the disease mechanisms we investigate in our current paper, Giasson et al., 2003. The percentage of patients with Parkinson’s disease w
COMMENT The Wilson et al. paper is relevant to the findings in our paper. While the authors do not establish the extent of co-morbid tau and α-synuclein in their patient cohort, it is likely that this is occurring, and it emphasizes once again the clinical releva
COMMENT This study of the remarkable properties of peptides, initially investigated because they might yield insights into Alzheimer's disease, provides a vivid example of how biological research can take the most unexpected turns, with potential benefits ne
COMMENT In a longitudinal cohort study of 824 older Catholic clergy members (mean age at baseline 75.4, SD 6.9 years) without clinical evidence of AD or PD at baseline, Wilson et al. found that 114 persons (13.8 percent) developed AD over the course of an average
COMMENT This is an interesting article on the production of nanotubes by polymerization of a dipeptide inspired by the central hydrophobic region of the amyloid-β (Aβ) protein. The authors provide a detailed description of why they focused on Phe-Phe as the build
COMMENT This interesting review proposes that, under certain circumstances, microglia may enhance rather than retard neuronal survival. This hypothesis is contrary to the view held by many AD researchers that microglia have an entirely negative effect on neuronal
