11519 RESULTS
COMMENT Microglia in the human brain are not known to develop tau pathology but do play a significant role in propagation of tau pathology in animal models of tauopathy (Asai et al., 2015; Shi et al., 2019; Wang et al., 2022), in corticobasal syndrome (Palleis et
COMMENT This exciting work helps tie together several independent areas of research, including cellular senescence, lipid droplet formation, and mitochondrial dysfunction during aging. It has been previously reported that glia accumulate lipid droplets in respons
COMMENT Guo and colleagues advance our understanding of the biochemical processes behind γ-secretase-mediated cleavage of APP. Using cryo-EM of γ-secretase bound to APP-C99, Aβ49, Aβ46, and Aβ43, we are presented with the greatest insight yet of the sequential ge
COMMENT We read with great interest the report by Xuefei Guo et al. We just published structures of γ-secretase in an apo state as well as in complex with the intermediate Aβ46 substrate. Comparing these two independent studies has been particularly exciting. The
COMMENT This new study is another tour de force in structure elucidation of the γ-secretase complex from the labs of Rui Zhou in Beijing and Yigong Shi in Hangzhou. The snapshots of the protease bound to APP-derived C99, Aβ49, Aβ46, and Aβ43 reveal critical detai
COMMENT able to characterize astrocyte interactions with neurons. Zhang at al. comment that “attempts for
COMMENT We found the results in Miao et al. very intriguing. The authors have utilized an elegant approach to explore how fluorescent solutes are transported between different brain regions, by infusing the solutes into the striatum and detecting them using impla
COMMENT First and foremost, we would like to thank our colleagues for their comments. We appreciate the
COMMENT In this paper, Miao et al. present data that contradicts the findings of Xie et al., Science 2013, by showing that clearance is inhibited during sleep or under anesthesia. As the authors discuss, sleep and anesthesia may have different effects on the pene
COMMENT targets. In his comment, Mark Cookson raises the important question of how specific these changes in RNA
COMMENT This interesting study provides evidence that the class 4 semaphorin receptor Plexin-B1, which is prominently expressed by the astrocytes that surround amyloid beta plaques in Alzheimer’s disease, regulates both astrocyte spacing around, and microglia ass
COMMENT Andawei Miao and colleagues, in an elegant mouse model, scientifically challenge the concept of “enhanced glymphatic brain clearance during deep sleep,” which was born a decade ago, also in a mouse model. Over this decade, the original mouse model inspire
COMMENT We read this article with great interest. We found the results intriguing but believe the study has technical issues and potential for data misinterpretation. The authors suggest that brain solute clearance is independent of consciousness state and that c
COMMENT novel work, and for considering my comments. sarmad.peymaei_392536 0 The role of brain barriers in fluid
COMMENT We have about 50 patients on lecanemab now, compared to zero in January. The process is gradually working more smoothly as issues are worked out. However, we will need to continue to monitor as numbers increase further. christopher.vandyck_372206 0
