11518 RESULTS
COMMENT Overall, this manuscript provides provocative novel observations and hypotheses that expand our knowledge of the potential roles of C1q, a recognition component of the innate immune system and of the classical complement pathway. C1q has been shown to be
COMMENT This exciting and thought-provoking work by Scott-Hewitt et al. uncovers a new intraneuronal function for the microglial secreted protein C1q. The authors performed C1q co-immunoprecipitation from synaptosomes isolated from developing, young adult, and ad
COMMENT The study unveils the fascinating and unexpected discovery that C1q regulates protein homeostasis in the aging brain independently of its role in the complement pathway. Our research, along with that of others, including Beth Stevens’ lab, has demonstrate
COMMENT This is an incredibly well-done and compelling study that convincingly demonstrates that a microglial-derived protein is taken up by neurons and modulates their function. We know that C1q has a diverse array of functions, particularly in the extracellular
COMMENT Until about 10 years ago, neutrophils were considered a homogenous population of short lived, terminally differentiated cells with low transcriptional capacity that release a limited number of cytokines, suggesting highly conserved, specialized immune and
COMMENT The study by Rosenzweig et al. on the sex-dependent interactions between APOE4 neutrophils and microglia in Alzheimer's disease is very interesting and important. The authors have elegantly demonstrated the critical role of IL-17 signaling in cogniti
COMMENT This study is of interest as it provides new insights into the sex dependence of the impact of ApoE4 on AD pathobiology. The inclusion of human data combined with experimental validation are major strengths of the paper. The identification of a new class
COMMENT These parallel discoveries by the Lee and Ryskeldi-Falcon teams are seminal. Together, they conclusively show that two distinct proteins, ANXA11 and TDP-43, co-assemble into organized heteromeric amyloid filaments in FTLD type C and in a subset of other T
COMMENT I think this is a very interesting and exciting discovery for several reasons. The finding of a novel type of filament as a consistent feature of FTLD-TDP type C samples confirms that these cases represent a distinct entity, and validates the current path
COMMENT In the beginning, amyloid was identified by tell-tale morphologic and staining characteristics, and little was known about its constituent proteins. As analytic methods progressed, amyloids became increasingly defined by their principal polymeric proteins
COMMENT will proceed directly to our comments. In our previous work (Yin et al., 2023), we identified
COMMENT Since the development of tau PET tracers capable of detecting the 3R/4R tau pathology in Alzheimer’s disease, there have been increased efforts to find new tracers that specifically detect 4R tau in PSP and CBD. This work by Lindberg et al. from the Vasd
COMMENT Lindberg et al. provide compelling evidence for OXD-2314 as a new lead candidate for imaging non-AD tauopathies, and AD. Indeed, 3 HOXD-2314 had selective and stronger binding affinity for tau aggregates of PSP and CBD in postmortem tissue compared with o
COMMENT The development of [18F]OXD-2314 heralds a promising advance in the imaging of tauopathies, particularly the non-Alzheimer's disease (non-AD) type. This new tracer, designed through a ligand-based approach, shows high affinity and selectivity for 4R-
COMMENT Mathis, Vasdev, and colleagues provide a model protocol for designing and evaluating PET radioligands based on chemical, pharmacokinetic, and pharmacodynamic properties. The validity of this approach will soon be examined by a clinical PET study for AD an
