PAPER Mao M, Zhou Y, Zhang H, Deng P, Yang J, Zhong J, Li N, Liu Q, Li X, Wu X, Cheng Y

Synthesis and identification of azocoumarin derivatives toward imaging of α-synuclein aggregates in the brain.

Eur J Med Chem. 2025 Jun 5;290:117587. Epub 2025 Mar 29 PubMed.

PAPER Mejia-Gutierrez M, Moser B, Pirlot M, Zhang H, Chumala P, Katselis GS, Palmer DR, Krol ES

Caffeine and Nicotine with N-Substituted Diazirine Photoaffinity Labels Form Adducts at Tyrosine-39 of α-Synuclein.

ACS Chem Neurosci. 2025 Apr 16;16(8):1539-1549. Epub 2025 Apr 1 PubMed.

Jean Eddy Bien-Aime

CIUSSS CN
Canada

Bart De Strooper on The Bad Medicine of Doctored

COMMENT I share Jeremy Berg’s concerns and am deeply disappointed by the stance taken by Science and the AAAS, which appears to support the propagation of a damaging, biased, and unscientific narrative. Endorsing such a perspective risks distorting public underst

Bart De Strooper on Donanemab Clinical Use Growing in U.S., Rejected in Europe

COMMENT A similar situation occurred with lecanemab, which was rejected by the EMA on the grounds that its benefits did not sufficiently outweigh the risks of potentially fatal ARIA events. In the case of donanemab, the decision appears to have been influenced by

Maria Carrillo on The Bad Medicine of Doctored

COMMENT As Alzheimer’s science rapidly evolves, the scientific community has a responsibility to ensure the information presented to people facing Alzheimer’s disease or a related dementia is accurate and grounded in the latest science. However, increasingly, a s