PAPER

Novel mRNA isoforms in human microglia refine genetic associations with neurodegeneration.

Nat Genet. 2025 Mar 7; Epub 2025 Mar 7 PubMed.

PAPER Eide PK

Adult Hydrocephalus and the Glymphatic System.

Neurosurg Clin N Am. 2025 Apr;36(2):127-140. Epub 2025 Feb 5 PubMed.

PAPER Lu Q, Shao N, Fang Z, Ouyang Z, Shen Y, Yang R, Liu H, Cai B, Wei T

The anti-Alzheimer's disease effects of ganoderic acid A by inhibiting ferroptosis-lipid peroxidation via activation of the NRF2/SLC7A11/GPX4 signaling pathway.

Chem Biol Interact. 2025 Mar 5;412:111459. Epub 2025 Mar 5 PubMed.

PAPER Parhizkar S, Holtzman DM

The night's watch: Exploring how sleep protects against neurodegeneration.

Neuron. 2025 Feb 27; Epub 2025 Feb 27 PubMed.

PAPER Tserennadmid B, Nam MK, Park JH, Rhim H, Kang S

HAP/ClpP-mediated disaggregation and degradation of Mutant SOD1 aggregates: A potential therapeutic strategy for Amyotrophic lateral sclerosis (ALS).

Biochem Biophys Res Commun. 2025 Feb 28;756:151533. Epub 2025 Feb 28 PubMed.

PAPER T S S, N K

Taylor-dingo optimized RP-net for segmentation toward Alzheimer's disease detection and classification using deep learning.

Comput Biol Chem. 2025 Jun;116:108359. Epub 2025 Feb 13 PubMed.

PAPER Wu M, Zhang R, Fu P, Mei Y

Disrupted astrocyte-neuron signaling reshapes brain activity in epilepsy and Alzheimer's disease.

Neuroscience. 2025 Mar 27;570:132-151. Epub 2025 Feb 20 PubMed.

PAPER Rahman AU, Ali S, Saqia B, Halim Z, Al-Khasawneh MA, AlHammadi DA, Khan MZ, Ullah I, Alharbi M

Alzheimer's disease prediction using 3D-CNNs: Intelligent processing of neuroimaging data.

SLAS Technol. 2025 Mar 6;32:100265. Epub 2025 Mar 6 PubMed.

Leon French on Sex Differences in Blood of Alzheimer’s and Parkinson’s Patients

COMMENT I commend Grandke et al. for highlighting that their strongest pathway-level signal, "SRP-dependent cotranslational protein targeting to membrane," aligns with the gingipain hypothesis. This pathway primarily comprises ribosomal proteins, e.g. R

PAPER Avey DR, Ng B, Vialle RA, Kearns NA, Lopes Kd, Iatrou A, Tissera SD, Vyas H, Saunders DM, Flood DJ, Xu J, Tasaki S, Gaiteri C, Bennett DA, Wang Y

Uncovering Plaque-Glia Niches in Human Alzheimer's Disease Brains Using Spatial Transcriptomics

bioRxiv2024.09.05.611566 .

PSEN1 Q223K

MUTATIONS PSEN1 73659470 GRCh37/hg19 rs1898776259 C A 73192762 GRCh38/hg38 rs1898776259 C A Exon 7 Coding Increased Aβ42 levels and the Aβ42/Aβ40 ratio in cells. Unknown. Q223K Alzheimer's Disease: Not ClassifiedAlzheimer's Disease Detailed information on

PSEN1 W165L

MUTATIONS PSEN1 73653574 GRCh37/hg19 rs1898534725 G T 73186866 GRCh38/hg38 G T Exon 6 Coding Unknown, but predicted deleterious in silico (PHRED-scaled CADD score = 28.3). Unknown. W165L Alzheimer's Disease: Not ClassifiedAlzheimer's Disease Detailed info

Yizhou A. Liu

Washington University in St Louis School of Medicine
United States

PAPER Saikusa K, Kinumi T, Kato M

Development of amyloid β (1-42) certified reference material NMIJ CRM 6210-a.

Anal Bioanal Chem. 2025 Mar 5; Epub 2025 Mar 5 PubMed.

PAPER Limone A, Di Napoli C, Napolitano F, Imbò B, Minopoli G, Bagnoli S, Izzo A, Paladino S, Nacmias B, De Matteis MA, Montuori N, Lavecchia A, Sarnataro D

Targeting RPSA to modulate endosomal trafficking and amyloidogenesis in genetic Alzheimer's disease.

Biochim Biophys Acta Mol Basis Dis. 2025 Mar 2;1871(5):167753. Epub 2025 Mar 2 PubMed.