Paulo Santos
Brazil
364 RESULTS
Brazil
MUTATIONS PSEN1 73664786 GRCh37/hg19 G A 73198078 GRCh38/hg38 G A EXON 8 Coding Unknown, but predicted deleterious in silico (PHRED-scaled CADD score = 33). Unknown. E273K Alzheimer's Disease: Not ClassifiedAlzheimer's Disease GAA E AAA K 273
MUTATIONS PSEN1 73664751 GRCh37/hg19 rs199723282 T C 73198043 GRCh38/hg38 T C Exon 8 Coding Unknown, but predicted deleterious in silico (PHRED-scaled CADD score = 25.9). Unknown. V261A Alzheimer's Disease: Not ClassifiedAlzheimer's Disease Detailed infor
MUTATIONS PSEN1 73659528 GRCh37/hg19 C A 73192820 GRCh38/hg38 C A Exon 7 Coding Increased the Aβ42/Aβ40 ratio, but both Aβ42 and Aβ40 levels were decreased in cells. Unknown. P242H Alzheimer's Disease: Not ClassifiedAlzheimer's Disease Detailed informatio
COMMENT This paper by Chen and colleagues provides new insight into the delicate balance between immune cells and the brain, particularly at the barriers that serve as physiological interfaces between these two systems. Specifically, the authors focus on how the
COMMENT Autoimmune disorders are more prevalent in females versus males, and a molecular clue is that Xist long noncoding RNA (lncRNA) ribonucleoproteins are a promoter of sex-biased autoimmunity (Dou et al., 2024), and Xist appears in the cytoplasm of AD (Sen an
PAPER Sen S, Mukhopadhyay D
PAPER Dou DR, Zhao Y, Belk JA, Zhao Y, Casey KM, Chen DC, Li R, Yu B, Srinivasan S, Abe BT, Kraft K, Hellström C, Sjöberg R, Chang S, Feng A, Goldman DW, Shah AA, Petri M, Chung LS, Fiorentino DF, Lundberg EK, Wutz A, Utz PJ, Chang HY
Maastricht University
Netherlands
German Center for Neurodegenerative Diseases (DZNE)
Germany
PAPER Jiang P, Dickson DW
PAPER Yu J, Zhou R, Liu S, Zheng J, Yan H, Su S, Chai N, Segal E, Jiang C, Guo K, Li CZ
PAPER Vostrý M, Chytrý V, Cmorej PC, Fleischmann O, Kubová N
PAPER Koller EJ, McFarland KN, Angelle C, Howard J, Ryu D, Dillon KD, Erquizi A, Beheray M, De La Cruz EG, Cruz PE, Lewis J, Golde TE, Levites Y, Chakrabarty P
PAPER Pateras J, Zhang C, Majumdar S, Pal A, Ghosh P