PSEN1 P242H

MUTATIONS PSEN1 73659528 GRCh37/hg19 C A 73192820 GRCh38/hg38 C A Exon 7 Coding Increased the Aβ42/Aβ40 ratio, but both Aβ42 and Aβ40 levels were decreased in cells. Unknown. P242H Alzheimer's Disease: Not ClassifiedAlzheimer's Disease Detailed informatio

Michal Schwartz on With Age, Macrophages Chew up the Blood-CSF Barrier

COMMENT This paper by Chen and colleagues provides new insight into the delicate balance between immune cells and the brain, particularly at the barriers that serve as physiological interfaces between these two systems. Specifically, the authors focus on how the

Charles Stromeyer on Can Autoimmunity Spark Alzheimer’s Disease?

COMMENT Autoimmune disorders are more prevalent in females versus males, and a molecular clue is that Xist long noncoding RNA (lncRNA) ribonucleoproteins are a promoter of sex-biased autoimmunity (Dou et al., 2024), and Xist appears in the cytoplasm of AD (Sen an

PAPER Sen S, Mukhopadhyay D

Aberrant XIST beyond the inactivated X chromosome modulates the intracellular dysregulation in Alzheimer’s disease

Alzheimer's Association, 3 January 2025 . Alzheimer's Association

PAPER Dou DR, Zhao Y, Belk JA, Zhao Y, Casey KM, Chen DC, Li R, Yu B, Srinivasan S, Abe BT, Kraft K, Hellström C, Sjöberg R, Chang S, Feng A, Goldman DW, Shah AA, Petri M, Chung LS, Fiorentino DF, Lundberg EK, Wutz A, Utz PJ, Chang HY

Xist ribonucleoproteins promote female sex-biased autoimmunity.

Cell. 2024 Feb 1;187(3):733-749.e16. PubMed.

Aurore Delvenne

Maastricht University
Netherlands

Lis de Weerd

German Center for Neurodegenerative Diseases (DZNE)
Germany

PAPER Jiang P, Dickson DW

Correlative light and electron microscopy imaging of proteinaceous deposits in cell cultures and brain tissues.

Acta Neuropathol Commun. 2025 Mar 8;13(1):53. PubMed.

PAPER Yu J, Zhou R, Liu S, Zheng J, Yan H, Su S, Chai N, Segal E, Jiang C, Guo K, Li CZ

Electrochemical Biosensors for the Detection of Exosomal microRNA Biomarkers for Early Diagnosis of Neurodegenerative Diseases.

Anal Chem. 2025 Mar 9; Epub 2025 Mar 9 PubMed.

PAPER Vostrý M, Chytrý V, Cmorej PC, Fleischmann O, Kubová N

Effect of combined and intensive rehabilitation on cognitive function in patients with Alzheimer's disease evaluated through a randomized controlled trial.

Sci Rep. 2025 Mar 8;15(1):8110. PubMed.

PAPER Koller EJ, McFarland KN, Angelle C, Howard J, Ryu D, Dillon KD, Erquizi A, Beheray M, De La Cruz EG, Cruz PE, Lewis J, Golde TE, Levites Y, Chakrabarty P

Antagonizing Il10 and Il4 signaling via intracerebral decoy receptor expression attenuates Aβ accumulation.

Acta Neuropathol Commun. 2025 Mar 7;13(1):51. PubMed.

PAPER Pateras J, Zhang C, Majumdar S, Pal A, Ghosh P

Physics-informed machine learning for automatic model reduction in chemical reaction networks.

Sci Rep. 2025 Mar 7;15(1):7980. PubMed.

PAPER Sharbafshaaer M, Siciliano M, Passaniti C, Sant'Elia V, Silvestro M, Russo A, Esposito S, Tedeschi G, Trojano L, Trojsi F

Screening of visuospatial abilities in amyotrophic lateral sclerosis (ALS): a pilot study using the battery for visuospatial abilities (BVA).

Orphanet J Rare Dis. 2025 Mar 8;20(1):110. PubMed.

PAPER Lee S, Hahn C, Seong E, Choi HS

Corrigendum to "Reactive EEG biomarkers for diagnosis and prognosis of Alzheimer's disease and mild cognitive impairment" [Biosens. Bioelectron. 273 (2025) 117181].

Biosens Bioelectron. 2025 Mar 7;:117348. Epub 2025 Mar 7 PubMed. Corrected paper.

PAPER Zhao J, Li Z, Zhang R, Yu H, Zhang L

Network pharmacology mechanism of Rosmarinus officinalis L.(Rosemary) to improve cell viability and reduces apoptosis in treating Alzheimer's disease.

BMC Complement Med Ther. 2025 Mar 7;25(1):94. PubMed.