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In Amyloidosis, EphA4 Goads Astrocytes to Massacre Synapses

RESEARCH NEWS 2025-03-07 Research News Astrocytes are notoriously two-faced—calmly coddling neurons one minute, then ruthlessly consuming their synapses the next. Why these dramatic mood swings? Blame the EphA4 receptor, according to a study published February 18 in Proceedings o

APP L723R

MUTATIONS APP 27264077 GRCh37/hg19 T G 25891765 GRCh38/hg38 T G Exon 17 Coding Increased Aβ42 and decreased Aβ40 levels resulting in an increased Aβ42/Aβ40 ratio in cells. Unknown. L723R Alzheimer's Disease: Not ClassifiedAlzheimer's Disease This variant

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