COMMENT In his seminal publication of 1911 titled “Über eigenartige Krankheitsfälle des späteren Alters“ (On peculiar diseases of older age), Alois Alzheimer already noted that epileptiform activity is a common symptom of “his” disease, but it took about a centur

Nicolai Franzmeier, Sebastian N. Roemer-Cassiano on By Cleaving GABA(A) Receptors, BACE1 Lifts Lid on Hyperactivity

COMMENT In this insightful study, Bi et al. identify a novel mechanism linking Aβ pathology to neuronal hyperexcitability via BACE1-mediated impairment of inhibitory GABAergic signaling. Best known for its role in Aβ generation, the BACE1 enzyme is shown here to

Laura Volpicelli-Daley on Parkinson’s Risk Gene Speeds Spread of α-Synuclein Pathology

COMMENT What first struck me about this study was the incredible amount of work that went into the paper. I particularly appreciated that all data shown was an average from several independent experiments and the authors were completely open with the Ns. Wu and c

Sebastian N. Roemer-Cassiano

LMU Hospital

Joy Zuchero on Do Specialized Glycoproteins Prop Up Blood-Brain Barrier?

COMMENT The glycocalyx of the BBB has been an underappreciated aspect of the neurovasculature, but emerging data in the past few years suggest it plays an important role in maintaining BBB integrity, especially in disease and injury. This publication from Shi et

Christian Alzheimer

University of Erlangen-Nuremberg
, Germany

Ricky Wang

PAPER Bieluszewska A, Wulfridge P, Fang KC, Hong Y, Sawada T, Erwin J, Song H, Ming GL, Sarma K

Transcriptomic Analysis Uncovers an Unfolded Protein Response in ADNP Syndrome.

Mol Cell Biol. 2025 Feb 14;:1-11. Epub 2025 Feb 14 PubMed.

Go to another page:

Current Filters

Date Range : Mar 2025 to Mar 2025 x

Remove all filters

SEARCH RESULTS

Advanced strategies for enhancing the neuroprotective potential of curcumin: delivery systems and mechanistic insights in neurodegenerative disorders.

Should people be able to have access to medical assistance in dying to avoid living with Alzheimer's? Opinions from Mexico and Colombia.

Genetic geroscience and Alzheimer's disease: The pleiotropy is the point!

Mitochondrial dysfunction in Alzheimer's disease.

Carrie Tse

Experimental basis for generating nonhuman primate models of frontotemporal dementia and Alzheimer's disease.

Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes.

Christian Alzheimer on By Cleaving GABA(A) Receptors, BACE1 Lifts Lid on Hyperactivity