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Aberrant XIST beyond the inactivated X chromosome modulates the intracellular dysregulation in Alzheimer’s disease

Alzheimer's Association, 3 January 2025 . Alzheimer's Association

PAPER Dou DR, Zhao Y, Belk JA, Zhao Y, Casey KM, Chen DC, Li R, Yu B, Srinivasan S, Abe BT, Kraft K, Hellström C, Sjöberg R, Chang S, Feng A, Goldman DW, Shah AA, Petri M, Chung LS, Fiorentino DF, Lundberg EK, Wutz A, Utz PJ, Chang HY

Xist ribonucleoproteins promote female sex-biased autoimmunity.

Cell. 2024 Feb 1;187(3):733-749.e16. PubMed.

Aurore Delvenne

Maastricht University
Netherlands

Lis de Weerd

German Center for Neurodegenerative Diseases (DZNE)
Germany

PAPER Nordvall G, Yan P, Agholme L, Lundkvist J, Sandin J, Biverstål H, Winblad B, Zetterberg H, Klintenberg R, Ferm M, Cirrito JR, Lee JM

γ-Secretase modulation inhibits amyloid plaque formation and growth and stimulates plaque regression in amyloid precursor protein/presenilin-1 mice.

J Pharmacol Exp Ther. 2025 Feb 12;392(4):103400. Epub 2025 Feb 12 PubMed.

PAPER Jiang P, Dickson DW

Correlative light and electron microscopy imaging of proteinaceous deposits in cell cultures and brain tissues.

Acta Neuropathol Commun. 2025 Mar 8;13(1):53. PubMed.

PAPER Yan S, Zhang W, Li X, Dutta S, Castle AR, Liu Y, Sahoo A, Lam CL, Gatford NJ, Hu MT, Li CZ, Jiang C, Shu B, Tofaris GK

Single extracellular vesicle detection assay identifies membrane-associated α-synuclein as an early-stage biomarker in Parkinson's disease.

Cell Rep Med. 2025 Mar 3;:101999. Epub 2025 Mar 3 PubMed.

PAPER Spargo TP, Sands CF, Juan IR, Mitchell J, Ravanmehr V, Butts JC, De-Paula RB, Kim Y, Hu F, Wang Q, Vitsios D, Garg M, Middleton L, Tyrlik M, Messa M, Del Angel G, Calame DG, Saade H, Robak L, Hollis B, Cuddapah VA, Zoghbi HY, Shulman JM, Petrovski S, Al-Ramahi I, Tachmazidou I, Dhindsa RS

Haploinsufficiency of ITSN1 is associated with a substantial increased risk of Parkinson's disease.

Cell Rep. 2025 Mar 4;:115355. Epub 2025 Mar 4 PubMed.

PAPER Kimura K, Tanaka MT, Miki Y, Furukawa T, Kasai S, Ozaki T, Mori F, Shibuya E, Wakabayashi K

Intranasal administration of ergothioneine improves memory in a mouse model of multiple system atrophy.

Biochem Biophys Res Commun. 2025 Feb 28;756:151550. Epub 2025 Feb 28 PubMed.

PAPER Mielke MM, Fowler NR, Whitson HE, Klepin HD, Trammell AR, Kulshreshtha A, O'Brien KS, Manchester M, Salive ME, Williamson J

Proceedings of the Alzheimer's Diagnosis in Older Adults with Chronic Conditions (ADACC) Network Inaugural Annual Conference.

J Gerontol A Biol Sci Med Sci. 2025 Mar 9; Epub 2025 Mar 9 PubMed.

PAPER Lee H, Shin S, Nam G, Kwak S, Cho YS, Hwang E, Oh S, Kim SY, Yoo SY, Lee JY

Longitudinal trajectories of cognitive, functional, and neuropsychiatric decline in Alzheimer's disease during COVID-19 lockdown in South Korea.

Sci Rep. 2025 Mar 8;15(1):8081. PubMed.

PAPER Liew TM

Distinct trajectories of subjective cognitive decline before diagnosis of neurocognitive disorders: Longitudinal modelling over 18 years.

J Prev Alzheimers Dis. 2025 Mar 7;:100123. Epub 2025 Mar 7 PubMed.

PAPER Lee S, Hahn C, Seong E, Choi HS

Corrigendum to "Reactive EEG biomarkers for diagnosis and prognosis of Alzheimer's disease and mild cognitive impairment" [Biosens. Bioelectron. 273 (2025) 117181].

Biosens Bioelectron. 2025 Mar 7;:117348. Epub 2025 Mar 7 PubMed. Corrected paper.

PAPER Xu C

Enhanced social interaction protects cognition by preserving synapse numbers.

Brain Res. 2025 Mar 6;1854:149552. Epub 2025 Mar 6 PubMed.

PAPER Mielke MM, Fielding RA, Atkinson EJ, Aversa Z, Schafer MJ, Cummings SR, Pahor M, Leeuwenburgh C, LeBrasseur NK

Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study.

J Nutr Health Aging. 2025 Mar 7;29(5):100529. Epub 2025 Mar 7 PubMed.