COMMENT Previous cross-sectional studies have indicated higher tau deposition in women, but there has been limited evidence from longitudinal studies suggesting females exhibit faster tau accumulation on average (Smith et al., 2020; Wang et al., 2024). This large

ASCB/EMBO Meeting: CELL BIO 25

CONFERENCE 2025-12-06 00:00:00-2025-12-10 00:00:00 Philadelphia, Pennsylvania 06 &#x2013 10 December 2025 View Conference Website 0

Marco Colonna on After Immunotherapy, Amyloid Clearance Comes Down to Microglial Moods

COMMENT This exciting study explores the role of microglia in immune-mediated clearing of Aβ plaques in AD. The study integrated spatial transcriptomics, proteogenomics, and scRNA-Seq to analyze postmortem brain tissues from AD patients who received active or pas

Giulia Albertini, Bart De Strooper on After Immunotherapy, Amyloid Clearance Comes Down to Microglial Moods

COMMENT In an era where anti-Aβ therapies are transitioning into widespread clinical practice, research into elucidating their working mechanisms, as well as their side effects, is crucial. Lynn van Olst, David Gate, and colleagues present a beautifully executed

PAPER Albertini A, Zielonka M, Cuypers ML, van Lieshout V, Snellinx A, Pasciuto E, Wolfs L, Craessaerts K, Horré K, Jaspers T, Fiers M, Dewilde M, De Strooper B

Using anti‐Aβ antibodies to modulate the multi‐pronged human microglia response to Aβ pathology

Alzheimers Dement. 2025 Jan 3 . Alzheimers & Dementia

Cynthia Lemere on After Immunotherapy, Amyloid Clearance Comes Down to Microglial Moods

COMMENT These studies allow an initial glimpse into the microglial response and Aβ removal following active Aβ vaccination and passive AŴ immunization. The following caveats should be kept in mind: AN1792 patients were immunized with full-length Aβ1-42 and a stro

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Phenylpropanoids of Eleutherococcus senticosus (Rupr. & maxim.) maxim. Alleviate oxidative stress in Alzheimer's disease in vitro and in vivo models by regulating Mst1 and affecting the Nrf2/Sirt3 pathway.

A network-level transport model of tau progression in the Alzheimer's brain.

The Potential of cfDNA as Biomarker: Opportunities and Challenges for Neurodegenerative Diseases.

Targeting CB2 receptor with a novel antagonist reverses cognitive decline, neurodegeneration and pyroptosis in a TAU-dependent frontotemporal dementia mouse model.

Natural Products Targeting Tau Protein Phosphorylation: A Promising Therapeutic Avenue for Alzheimer's Disease.

IUPHAR review: From gut to brain: The role of gut dysbiosis, bacterial amyloids, and metabolic disease in Alzheimer's disease.

Transcriptional signatures of hippocampal tau pathology in primary age-related tauopathy and Alzheimer's disease.

Polymorphism in the LASP1 gene promoter region alters cognitive functions of patients with schizophrenia.

Population Stratification in Genetic Association Studies.

Joseph Therriault, Yi-Ting Wang on Confirmed: Women Accumulate Tangles Faster Than Do Men