5533 RESULTS
MUTATIONS APP 25891762 GRCh38/hg38 A T 27264074 GRCh37/hg19 A T Exon 17 Coding Increased Aβ42/Aβ40 ratio and Aβ42 levels in cultured cells. Unknown, but in one carrier, MRI revealed mild global brain atrophy and enlargement of the ventricles. K724M Alzheimer'
COMMENT The Aisen et al. Perspective article argues that robust reduction of amyloid PET signal achieved by Aβ antibody-based therapies should serve as a surrogate biomarker of clinical response for approval of such treatments. The article provides a convincing s
COMMENT It is interesting that the datasets, studies, and arguments presented in this perspective paper bring others to different conclusions, and with an equal degree of conviction. rswerdlow 0
COMMENT A surrogate marker for clinical outcomes in Alzheimer’s therapeutics has long been regarded as the Holy Grail in the field. It could definitely make new drug development much easier and faster. I agree with the authors of this position paper that, based o
Asan Medical Center
Korea, Republic of
PAPER Shankar G, Kumar P, Rai S, Ghosh A, Varma T, Wani MA, Kumar S, Mandloi U, Singh GK, Garg P, Kulkarni O, Srikrishna S, Kumar S, Modi G
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PAPER Molina-Henry D, Raman R
PAPER Bergström S, Mravinacová S, Lindberg O, Zettergren A, Westman E, Wahlund LO, Blennow K, Zetterberg H, Kern S, Skoog I, Månberg A
PAPER Liao Y, Chen HW, Qiu C, Shen H, He ZY, Song ZC, Zhou W
