PAPER Angehrn FN, Duan P, Zhang JY, Hong M

Binding Sites of a PET Ligand in Tau Fibrils with the Alzheimer's Disease Fold from 19F and 13C Solid-State NMR.

Biochemistry. 2025 Mar 11; Epub 2025 Mar 11 PubMed.

PAPER O'Neill K, Shaw R, Bolger I, NYGC ALS Consortium, Tam OH, Phatnani H, Gale Hammell M

ALS molecular subtypes are a combination of cellular and pathological features learned by deep multiomics classifiers.

Cell Rep. 2025 Mar 10;44(3):115402. Epub 2025 Mar 10 PubMed.

PAPER Writing Committee for the HEALEY ALS Platform Trial, Andrews J, Paganoni S, Macklin EA, Chibnik LB, Quintana M, Saville BR, Detry MA, Vestrucci M, Marion J, McGlothlin A, Young E, Chase M, Pothier L, Harkey B, Yu H, Sherman A, Shefner J, Hall M, Kittle G, Connolly MR, Berry JD, D'Agostino D, Tustison E, Giacomelli E, Scirocco E, Alameda G, Locatelli E, Ho D, Quick A, Heitzman D, Ajroud-Driss S, Appel SH, Shroff S, Katz J, Felice K, Maragakis NJ, Simmons Z, Goutman SA, Olney N, Miller T, Fernandes JA, Ilieva H, Jawdat O, Weiss MD, Foster L, Vu T, Ladha S, Owegi MA, Newman DS, Arcila-Londono X, Jackson CE, Swenson A, Heiman-Patterson T, Caress J, Fee D, Peltier A, Lewis R, Rosenfeld J, Walk D, Johnson K, Elliott M, Kasarskis EJ, Rutkove S, McIlduff CE, Bedlack R, Elman L, Goyal NA, Rezania K, Twydell P, Benatar M, Glass J, Cohen JA, Jones V, Zilliox L, Wymer JP, Beydoun SR, Shah J, Pattee GL, Martinez-Thompson J, Nayar S, Granit V, Donohue M, Grossman K, Campbell DJ, Qureshi IA, Cudkowicz ME, Babu S, HEALEY ALS Platform Trial Study Group

Verdiperstat in Amyotrophic Lateral Sclerosis: Results From the Randomized HEALEY ALS Platform Trial.

JAMA Neurol. 2025 Feb 17; Epub 2025 Feb 17 PubMed.

PAPER Bellelli F, Angioni D, Arosio B, Vellas B, De Souto Barreto P

Hallmarks of aging and Alzheimer's Disease pathogenesis: Paving the route for new therapeutic targets.

Ageing Res Rev. 2025 Apr;106:102699. Epub 2025 Feb 20 PubMed.

PAPER Chen X, Cao YG, Hao FX, Liu YL, Chi FG, Niu Y, Lu D, Zhao BX, Chen L, Zheng XK, Feng WS

Diketopiperazine and purine alkaloids from the tubers of Pinellia pedatisecta Schott and their protective activities against Aβ25-35-induced PC-12 cell injury.

Phytochemistry. 2025 Jun;234:114447. Epub 2025 Feb 19 PubMed.

PAPER Kim JW, Byun MS, Yi D, Jung JH, Kong N, Chang YY, Jung G, Ahn H, Lee JY, Kang KM, Sohn CH, Lee YS, Kim YK, Lee DY, KBASE Research Group #

Daily fluid intake and brain amyloid deposition: A cohort study.

J Alzheimers Dis. 2025 Mar;104(1):138-149. Epub 2025 Feb 21 PubMed.

PAPER Liang C, Okamoto AA, Karim F, Kawauchi S, Melkonyan L, Danh TB, Mukherjee J

Disruption of normal brain distribution of [18F]Nifene to α4β2* nicotinic acetylcholinergic receptors in old B6129SF2/J mice and transgenic 3xTg-AD mice model of Alzheimer's disease: In Vivo PET/CT imaging studies.

Neuroimage. 2025 Apr 1;309:121092. Epub 2025 Feb 18 PubMed.

PAPER Moore J, Wu T, Dhindsa J, El Fadel O, Le A, Perez A, Amoh B, Tarkunde A, Zhu KF, Avalos M, Dammer EB, Duong DM, Seyfried NT, Shulman JM, Al-Ramahi I, Botas J

Longitudinal multi-omics in alpha-synuclein Drosophila model discriminates disease- from age-associated pathologies in Parkinson's disease.

NPJ Parkinsons Dis. 2025 Mar 11;11(1):46. PubMed.

PAPER Almasoudi SH, Al-Kuraishy HM, Al-Gareeb AI, Eliwa D, Alexiou A, Papadakis M, Batiha GE

Role of mitogen-activated protein kinase inhibitors in Alzheimer's disease: Rouge of brain kinases.

Brain Res Bull. 2025 Mar 10;224:111296. Epub 2025 Mar 10 PubMed.

PAPER Wang T, He H, Shi Y, Su N, Zhu M, Yan F, Liu Y, Li J, Tang M, Chen W, Bao F, Wang H, Wang Y, Liu Y, Yuan Y, Zuo X, Zhang X, Cui L, Wu W, Zhang C, Lu Y, Fang Y, Xiao S

Prevalence, incidence and modifiable factors for subtypes of mild cognitive impairment: results from the Longitudinal Ageing Study in China.

Gen Psychiatr. 2025;38(2):e101736. Epub 2025 Mar 7 PubMed.

A Hyeon Lee

Korea Brain Research Institute
, Korea, Republic of

Kaitlin Casaletto on Confirmed: Women Accumulate Tangles Faster Than Do Men

COMMENT This paper is a massive accomplishment, representing the most robust evidence yet of female-specific vulnerability to tau aggregation. Applying a meta-analytic approach, the authors pooled estimates across six studies, including more than 1,300 participan

Pierre Tariot on Confirmed: Women Accumulate Tangles Faster Than Do Men

COMMENT This strikes me as a thoughtful and rigorous effort to improve our understanding of the apparent increased risk of having a diagnosis of AD in women than men, the reasons for which are not fully elucidated. The authors make a compelling case that women ex

Confirmed: Women Accumulate Tangles Faster Than Do Men

RESEARCH NEWS 2025-03-12 Research News Numerous studies have hinted that women are particularly susceptible to tau pathology, but scientists have lacked definitive data. Now, a meta-analysis of six longitudinal tau PET studies offers the strongest evidence yet. In the March 3 JAM

Nicolai Franzmeier, Davina Biel on Confirmed: Women Accumulate Tangles Faster Than Do Men

COMMENT This meta-analysis by Coughlan et al. provides robust evidence across six longitudinal cohorts, showing that women accumulate tau pathology faster than men in preclinical AD. This work is of high clinical relevance, as the transition from amyloidosis to t