Leon French

University of Toronto
Canada

With Age, Macrophages Chew up the Blood-CSF Barrier

RESEARCH NEWS 2025-03-05 Research News Protective borders between the brain and the blood weaken with age. This includes the barrier formed by tightly linked epithelial cells in the choroid plexus, which generates cerebrospinal fluid. In the February 26 Neuron online, scientists

Enrico Glaab

University of Luxembourg
Luxembourg

PAPER Freund A, Orjalo AV, Desprez PY, Campisi J

Inflammatory networks during cellular senescence: causes and consequences.

Trends Mol Med. 2010 May;16(5):238-46. Epub 2010 May 3 PubMed.

PAPER Silva-Vargas V, Maldonado-Soto AR, Mizrak D, Codega P, Doetsch F

Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells.

Cell Stem Cell. 2016 Nov 3;19(5):643-652. Epub 2016 Jul 21 PubMed.

Avi Dhariwal

PAPER Zheng W, Lin D, Shi S, Ren J, Wu J, Wang M, Wan S

Identifying shared diagnostic genes and mechanisms in vascular dementia and Alzheimer's disease via bioinformatics and machine learning.

J Alzheimers Dis Rep. 2024;8(1):1558-1572. Epub 2024 Nov 24 PubMed. Correction.

PAPER Noelker C, Seitz F, Sturn A, Neff F, Andrei-Selmer LC, Rau L, Geyer A, Ross JA, Bacher M, Dodel R

Autoantibodies against α-synuclein inhibit its aggregation and cytotoxicity.

J Autoimmun. 2025 Mar 3;152:103390. Epub 2025 Mar 3 PubMed.

PAPER Sabnam S, Kumar R, Pranav

Biofunctionalized nanomaterials for Parkinson's disease theranostics: potential for efficient PD biomarker detection and effective therapy.

Biomater Sci. 2025 Mar 4; Epub 2025 Mar 4 PubMed.

PAPER Leung KH, Chan VT, Lam BY, Mok VC, Cheung CY

Retinal vascular changes are associated with PET-based biomarkers of Alzheimer's disease: A pilot study.

J Alzheimers Dis Rep. 2024;8(1):1639-1648. Epub 2024 Dec 8 PubMed.

PAPER Chiang MT, Liu CJ, Lee BC, Yen RF, Tsai HH

Dual-Phase C-11 PiB PET Images for Detecting Tau Pathology in Cerebral Amyloid Angiopathy.

Ann Clin Transl Neurol. 2025 Mar 3; Epub 2025 Mar 3 PubMed.

PAPER Khowdiary MM, Al-Kuraishy HM, Al-Gareeb AI, Albuhadily AK, Elhenawy AA, Rashwan EK, Alexiou A, Papadakis M, Fetoh ME, Batiha GE

The Peripheral Amyloid-β Nexus: Connecting Alzheimer's Disease with Atherosclerosis through Shared Pathophysiological Mechanisms.

Neuromolecular Med. 2025 Mar 3;27(1):20. PubMed.

PAPER Abdelsalam SM, Matter AH, El-Hariri HM, Assaf AH, Khater MS, Tawfik HM

Adaptation and validation of the modified Egyptian Arabic version of Addenbrooke's Cognitive Examination III (VI-ACE-III) for assessing cognitive impairment in visually impaired elderly.

BMC Geriatr. 2025 Mar 4;25(1):145. PubMed.

PAPER Zhu Y, Wang A, Zhou Y, Yuan S, Ji Y, Hu W, Alzheimer’s disease Neuroimaging Initiative

Altered spatiotemporal consistency and their genetic mechanisms in mild cognitive impairment: a combined neuroimaging and transcriptome study.

Cereb Cortex. 2025 Feb 5;35(2) PubMed.

PAPER Gonzales MM, Fernandez R, Kremen S, Tan ZS, Werry AE, Jian X, Hart J, Royall D, Maestre G, Espinoza S, Seshadri S, Gelfond J, Wang CP

Predictors of bi-directional transitions from mild cognitive impairment in a diverse cohort.

J Gerontol A Biol Sci Med Sci. 2025 Feb 27; Epub 2025 Feb 27 PubMed.