PAPER Medeiros D, McMurry K, Pfeiffer M, Newsome K, Testerman T, Graf J, Silver AC, Sacchetti P
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Leonardo Tejo Gunawan
Hanyang UniversitySeoul, Korea, Republic of
Phillip Janowicz on Fast Plaque Clearance with Little ARIA? So Teases Trontinemab at AD/PD 2024
COMMENT Firstly, I think these results are fantastic and show the possibilities of BBB-crossing immunotherapy. The big question I would have thought is, have the patients been cured? Moreover, or alternatively, if the patients had been treated in their 20s, 30s,
TREM1 Muddles Myeloid Cell Metabolism and Memory in Old Mice
RESEARCH NEWS 2024-03-21 Research News The macrophage and microglial receptor TREM1 whips up inflammation. In its tizzy, the receptor also perturbs myeloid cell metabolism and hastens cognitive decline in older wild-type mice and in two models of amyloidosis, according to scienti
Michal Schwartz on TREM1 Muddles Myeloid Cell Metabolism and Memory in Old Mice
COMMENT The paper by Wilson et al. is extremely timely and important. It attributes a key role to myeloid cells in coping with aging in general, and age-related neurodegenerative diseases in particular, with an emphasis on Alzheimer’s disease, focusing on trigger
Elizabeth Bradshaw, Kirstin Tamucci on TREM1 Muddles Myeloid Cell Metabolism and Memory in Old Mice
COMMENT This paper highlights, and raises questions about, potential crosstalk between the peripheral immune system and central nervous system microglia and how this communication could be a powerful modulator of neurodegeneration. While the authors found very sm
PAPER Zhang C, Kan X, Zhang B, Ni H, Shao J
The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases.
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