PAPER Kubota M, Endo H, Takahata K, Tagai K, Suzuki H, Onaya M, Sano Y, Yamamoto Y, Kurose S, Matsuoka K, Seki C, Shinotoh H, Kawamura K, Zhang MR, Takado Y, Shimada H, Higuchi M

In vivo PET classification of tau pathologies in patients with frontotemporal dementia.

Brain Commun. 2024;6(2):fcae075. Epub 2024 Mar 1 PubMed.

PAPER Perales-Puchalt J, Peltzer J, Fracachan-Cabrera M, Perez GA, Ramírez M, Greiner KA, Burns JM

Authors' Response to Peer Reviews of "Impact of the COVID-19 Pandemic on Latino Families With Alzheimer Disease and Related Dementias: Qualitative Interviews With Family Caregivers and Primary Care Providers".

JMIRx Med. 2024 Mar 8;5:e56439. PubMed.

PAPER Shir D, Corriveau-Lecavalier N, Bermudez Noguera C, Barnard L, Pham NT, Botha H, Duffy JR, Clark HM, Utianski RL, Knopman DS, Petersen RC, Boeve BF, Murray ME, Nguyen AT, Reichard RR, Dickson DW, Day GS, Kremers WK, Graff-Radford NR, Jones DT, Machulda MM, Fields JA, Whitwell JL, Josephs KA, Graff-Radford J

Clinicoradiological and neuropathological evaluation of primary progressive aphasia.

J Neurol Neurosurg Psychiatry. 2024 Aug 16;95(9):812-821. PubMed.

PAPER Medeiros D, McMurry K, Pfeiffer M, Newsome K, Testerman T, Graf J, Silver AC, Sacchetti P

Slowing Alzheimer's disease progression through probiotic supplementation.

Front Neurosci. 2024;18:1309075. Epub 2024 Mar 6 PubMed.

Leonardo Tejo Gunawan

Hanyang University
Korea, Republic of

Phillip Janowicz on Fast Plaque Clearance with Little ARIA? So Teases Trontinemab at AD/PD 2024

COMMENT Firstly, I think these results are fantastic and show the possibilities of BBB-crossing immunotherapy. The big question I would have thought is, have the patients been cured? Moreover, or alternatively, if the patients had been treated in their 20s, 30s,

TREM1 Muddles Myeloid Cell Metabolism and Memory in Old Mice

RESEARCH NEWS 2024-03-21 Research News The macrophage and microglial receptor TREM1 whips up inflammation. In its tizzy, the receptor also perturbs myeloid cell metabolism and hastens cognitive decline in older wild-type mice and in two models of amyloidosis, according to scienti

Michal Schwartz on TREM1 Muddles Myeloid Cell Metabolism and Memory in Old Mice

COMMENT The paper by Wilson et al. is extremely timely and important. It attributes a key role to myeloid cells in coping with aging in general, and age-related neurodegenerative diseases in particular, with an emphasis on Alzheimer’s disease, focusing on trigger

Elizabeth Bradshaw, Kirstin Tamucci on TREM1 Muddles Myeloid Cell Metabolism and Memory in Old Mice

COMMENT This paper highlights, and raises questions about, potential crosstalk between the peripheral immune system and central nervous system microglia and how this communication could be a powerful modulator of neurodegeneration. While the authors found very sm

PAPER Zhang C, Kan X, Zhang B, Ni H, Shao J

The role of triggering receptor expressed on myeloid cells-1 (TREM-1) in central nervous system diseases.

Mol Brain. 2022 Oct 22;15(1):84. PubMed.

PAPER Andreasson KI, Wilson EN, Wang C, Xin M, Panchal M, Rabinowitz JD, Minhas PS, Swarovski MS, Benitez JA, Durairaj AS, Chaney A, Iweka CA, Buckwalter MS, Ennerfelt HE, Umans J, Huang J, Zera KA, McReynolds MR, Greicius MD, James ML, Mehta SS, LeGuen Y, Tan YJ, Zuckerman AJ, Blacher E, Gauba E, Serrano GE, Cropper H, Jain P, Liu Q

TREM1 disrupts myeloid bioenergetics and cognitive function in aging and Alzheimer disease models

bioRxiv2024.03.05.583562 .

PAPER Topriceanu CC, Shah M, Webber M, Chan F, Shiwani H, Richards M, Schott J, Chaturvedi N, Moon JC, Hughes AD, Hingorani AD, O'Regan DP, Captur G

APOE ε4 carriage associates with improved myocardial performance from adolescence to older age.

BMC Cardiovasc Disord. 2024 Mar 21;24(1):172. PubMed.

Ksenia Kastanenka on Do Sleep Rhythms Create Ion Waves That Rinse the Brain?

COMMENT Fantastic work by both groups. The work by Jonathan Kipnis and colleagues could provide an additional explanation for why we saw plaque clearance in APP/PS1 mice after optogenetic rescue of slow waves during sleep. kkastanenka_305846 0 Sleep restoration b

Nadine Urbach

, Germany

PAPER Schrag A, Kostev K

Association of antihypertensives and Parkinson's disease in a primary care population matched for underlying diagnosis.

PLoS One. 2024;19(3):e0299985. Epub 2024 Mar 20 PubMed.