PAPER Legault-Denis C, Aumont É, Onuska KM, Schmitz TW, Bussy A, Chakravarty M, Soucy JP, Bédard MA

Parkinson's disease CA2-CA3 hippocampal atrophy is accompanied by increased cholinergic innervation in patients with normal cognition but not in patients with mild cognitive impairment.

Brain Imaging Behav. 2024 Aug;18(4):783-793. Epub 2024 Mar 13 PubMed.

PAPER AlMansoori ME, Jemimah S, Abuhantash F, AlShehhi A

Predicting early Alzheimer's with blood biomarkers and clinical features.

Sci Rep. 2024 Mar 13;14(1):6039. PubMed. Correction.

PAPER Heise V, Offer A, Whiteley W, Mackay CE, Armitage JM, Parish S

A comprehensive analysis of APOE genotype effects on human brain structure in the UK Biobank.

Transl Psychiatry. 2024 Mar 12;14(1):143. PubMed.

Jin Ren

Amy Shapley-Fareell

Infectious Diseases Society of America
United States

Yara Alkhodair

University of British Columbia (UBC)
Canada

Nitasha Manchanda

United States

Paper Alert: APOE4 Packs on Lipid Droplets in Microglia

RESEARCH NEWS 2024-03-13 Research News Last year, scientists led by Tony Wyss-Coray, Stanford University, reported that Aβ induced formation of lipid droplets within human microglia, and attributed this to an uptick in a triglyceride synthesis enzyme. APOE4 aggravated lipid dropl

PAPER Rutledge J, Lehallier B, Zarifkar P, Losada PM, Shahid-Besanti M, Western D, Gorijala P, Ryman S, Yutsis M, Deutsch GK, Mormino E, Trelle A, Wagner AD, Kerchner GA, Tian L, Cruchaga C, Henderson VW, Montine TJ, Borghammer P, Wyss-Coray T, Poston KL

Comprehensive proteomics of CSF, plasma, and urine identify DDC and other biomarkers of early Parkinson's disease.

Acta Neuropathol. 2024 Mar 11;147(1):52. PubMed.

PAPER Summa KC, Jiang P, González-Rodríguez P, Huang X, Lin X, Vitaterna MH, Dan Y, Surmeier DJ, Turek FW

Disrupted sleep-wake regulation in the MCI-Park mouse model of Parkinson's disease.

NPJ Parkinsons Dis. 2024 Mar 11;10(1):54. PubMed.

PAPER Zilinskas R, Li C, Shen X, Pan W, Yang T

Inferring a directed acyclic graph of phenotypes from GWAS summary statistics.

Biometrics. 2024 Jan 29;80(1) PubMed.

PAPER Zhang G, Zhou Y, Hu Y, Xu H, Weng C, Peng Y

A span-based model for extracting overlapping PICO entities from randomized controlled trial publications.

J Am Med Inform Assoc. 2024 Apr 19;31(5):1163-1171. PubMed.

PAPER Weaver DF

Drug Design for Alzheimer's Disease: Biologics vs. Small Molecules.

Curr Alzheimer Res. 2024;20(12):821-826. PubMed.

PAPER De A, Mishra TK, Saraf S, Tripathy B, Reddy SS

A Review on the Use of Modern Computational Methods in Alzheimer's Disease-Detection and Prediction.

Curr Alzheimer Res. 2024;20(12):845-861. PubMed.

PAPER Lee MJ, Bhattarai D, Jang H, Baek A, Yeo IJ, Lee S, Miller Z, Lee S, Hong JT, Kim DE, Lee W, Kim KB

Correction to "Macrocyclic Immunoproteasome Inhibitors as a Potential Therapy for Alzheimer's Disease".

J Med Chem. 2024 Mar 28;67(6):5109-5110. Epub 2024 Mar 12 PubMed.