349199 RESULTS
CONFERENCE COVERAGE 2025-04-17 Conference Coverage Signaling through the TREM2 receptor fuels an ever-growing list of known microglial functions in the brain, and gene variants that hobble TREM2 signaling beckon Alzheimer’s disease. Ergo, activating this receptor is an enticing therape
CONFERENCE COVERAGE 2025-04-17 Conference Coverage TREM2 created quite the buzz at this year’s AD/PD meeting, held April 1-5 in Vienna. In the wake of a TREM2 agonist’s demise, scientists presented optimistic findings from early phase trials of a fresh batch of agonists. Juxtaposing th
PAPER Eyo UB, Peng J, Swiatkowski P, Mukherjee A, Bispo A, Wu LJ
CONFERENCE COVERAGE 2025-04-17 Conference Coverage Ever since the discovery of AD risk-stoking variants of TREM2, the microglial receptor has given scientists seeking to nail down its function a run for their money. It binds many ligands, supports manifold microglial functions, and see
JOB 2025-04-17 Employer University of Pennsylvania Contact Research Statement: please provide a 1-page specific aims format page that describes a research project using neuroimaging in ADRD and specify how it relates to one of the 3 specializations described above.
COMMENT IkT-148009 is a patent-busting product of Imatinib, which is known for having poor CNS penetration. I wonder what is the CNS exposure of IkT-148009 in humans, and if the clinical failure is caused by poor exposure, not the efficacy of the drug. cheng_4182
Sweden
PAPER Fleming SM, Scott S, Hamad EJ, Herman DE, Holden JG, Yan L, Linning-Duffy K, Kemp CJ, Patterson JR, Miller KM, Kubik M, Kuhn N, Stoll AC, Duffy MF, Steece-Collier K, Cole-Strauss A, Lipton JW, Luk KC, Sortwell CE
PAPER Zhan L, Tan G, Dong J, Deng Z, Zou Y, Dan Z, Wang R, Luo Z, Zhu X
PAPER Zhao Y, Jia M, Ding C, Bao B, Li H, Ma J, Dong W, Gao R, Chen X, Chen J, Dai X, Zou Y, Hu J, Shi L, Liu X, Liu Z
PAPER Temedda MN, Garnier-Crussard A, Moutet C, Mouchoux C, Dauphinot V
PAPER Hodson R
PAPER Du K, Zuo YL, Zhang ZM, Li A, Zuo QH, Zhang CY, Guo R, Ping C, Du WS, Li SM
PAPER Ma YN, Wang Z, Tang W
PAPER Stocker H, Beyer L, Trares K, Stevenson-Hoare J, Rujescu D, Holleczek B, Beyreuther K, Schoettker B, Gerwert K, Brenner H
