348573 RESULTS
CONFERENCE COVERAGE 1999-10-24 Conference Coverage Yamin (122.9) presented evidence that the zinc metalloproteinase EC 3.4.24.15 (E24.15) plays a role in neuronal mediated degradation of Aβ. In fact transfection of neuroblastoma cells with antisense E24.15 allows the accumulation of Aβ
CONFERENCE COVERAGE 1999-10-24 Conference Coverage Several groups have reported a lack of phenotype in α-synuclein (α-S) transgenic mice, but it appears Lennart Mucke (122.10) has got it right. Mucke reported that inclusion bodies were obvious in PDGF promoter-driven α-S Tg mice as ear
CONFERENCE COVERAGE 1999-10-24 Conference Coverage Previous studies on the purification and characterization of the predominant extracellular Aβ degrading activity in the murine BV-2 microglial cell line demonstrated that insulin-degrading enzyme (IDE) or a novel protease indistinguish
CONFERENCE COVERAGE 1999-10-24 Conference Coverage The N- and C-terminals of synthetic Aβ1-42 were differentially labeled with 3H and 14C and then used as a probe to measure degradation by injection into rat hippocampus. Effects of various protease inhibitors and two dimensional HPLC a
CONFERENCE COVERAGE 1999-10-24 Conference Coverage That β-amyloid plays a central role in the pathogenesis of Alzheimer's disease is doubted by few investigators. However, pinning down the exact contribution amyloid makes has been remarkably difficult to accomplish. Novel hypothes
RESEARCH NEWS 1999-10-22 Research News It is likely that a process very reminiscent of that suggested for Aβ formation-fibrillar protein deposition-is to blame for the rare, inherited disorder Familial British Dementia (FBD), according to a report in the most recent Nature Neuros
RESEARCH NEWS 1999-10-21 Research News According to a report in tomorrow's Science, researchers have uncovered a strong candidate for β-secretase, the mystery enzyme that cleaves APP and allows Aβ to be formed in subsequent cleavages. Martin Cintron, Robert Vassar, Brian Ben
COMMENT In the news article cited above, two important facts need clarification. First, protofibrils are fibrillar. Second, the first demonstration that protofibrils were neurotoxic was published by my group, in collaboration with Drs. Hartley, Selkoe, and others
RESEARCH NEWS 1999-10-15 Research News From today's Journal of Neuroscience comes evidence that intermediate Aβ species could be damaging neurons. Dean Hartley, Dennis Selkoe, and their colleagues report that so-called "protofibrillar" Aβ (oligomers intermediate be
RESEARCH NEWS 1999-10-12 Research News Further evidence that ApoE is needed for deposition of the fibrillar form of Aβ in plaques was presented today at the American Neurological Association's annual meeting in Seattle today. David Holtzman and his colleagues at Washington U
RESEARCH NEWS 1999-09-22 Research News Protein misprocessing and aggregation have been observed in many neurodegenerative diseases, including Alzheimer’s, spongiform encephalopathies, Huntington’s, Parkinson’s and FTDP-17, but it has been difficult to untangle the causal relation
RESEARCH NEWS 1999-09-22 Research News Writing in the current Nature Neuroscience, Heather Cameron and Ronald D.G. McKay report that they were able to boost the rate of neurogenesis in the hippocampus of aging rats by lowering corticosteroid levels. The results support the hypoth
RESEARCH NEWS 1999-09-15 Research News In today's Journal of Neuroscience, Vivian Budnik, Laura Torroja, and their colleagues at the University of Massachusetts, Amherst, and Brandeis University, Massachusetts, provide evidence that under normal circumstances, APP is a criti
RESEARCH NEWS 1999-09-13 Research News In the current Nature Cell Biology, Susan Lindquis and Jiang Ma of the Howard Hughes Institute at the University of Chicago report that they were able to produce abnormal prion protein (PrP) conformations from normal PrP, apparently by causi
RESEARCH NEWS 1999-08-31 Research News Douglas Smith and his colleagues at the University of Pennsylvania may have filled a gap in research on long-term, neurodegeneration sequelae of brain injuries by showing Aβ and tau production in an animal model of brain trauma. Their porcin
