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RESEARCH NEWS 2025-03-15 Research News Screening large genetic datasets can uncover harbingers of neurodegenerative disorders such as Alzheimer’s disease. For AD, most older genome-wide association studies have relied heavily on participants with European ancestry, though evidenc
PAPER Lin CH, Yang S, Huang YJ, Lane HY
PAPER Hellwege JN, Keaton JM, Giri A, Gao X, Velez Edwards DR, Edwards TL
COMMENT Previous cross-sectional studies have indicated higher tau deposition in women, but there has been limited evidence from longitudinal studies suggesting females exhibit faster tau accumulation on average (Smith et al., 2020; Wang et al., 2024). This large
CONFERENCE 2025-12-06 00:00:00-2025-12-10 00:00:00 Philadelphia, Pennsylvania 06 – 10 December 2025 View Conference Website 0
COMMENT This exciting study explores the role of microglia in immune-mediated clearing of Aβ plaques in AD. The study integrated spatial transcriptomics, proteogenomics, and scRNA-Seq to analyze postmortem brain tissues from AD patients who received active or pas
COMMENT In an era where anti-Aβ therapies are transitioning into widespread clinical practice, research into elucidating their working mechanisms, as well as their side effects, is crucial. Lynn van Olst, David Gate, and colleagues present a beautifully executed
PAPER Albertini A, Zielonka M, Cuypers ML, van Lieshout V, Snellinx A, Pasciuto E, Wolfs L, Craessaerts K, Horré K, Jaspers T, Fiers M, Dewilde M, De Strooper B
COMMENT These studies allow an initial glimpse into the microglial response and Aβ removal following active Aβ vaccination and passive AŴ immunization. The following caveats should be kept in mind: AN1792 patients were immunized with full-length Aβ1-42 and a stro
PAPER Holste K, Xia F, Garton HJ, Wan S, Hua Y, Keep RF, Xi G
COMMENT This paper is a key contribution, with far-reaching implications for the understanding of anti-amyloid antibody-based immunotherapies and the crucial role of microglial activity in efficient amyloid clearance. The authors identified significant unique and
RESEARCH NEWS 2025-03-14 Research News Plaques all but vanish in response to some Aβ immunotherapies. Scientists suspect microglia orchestrate the mop-up, but don’t know how, exactly. Now, David Gate of Northwestern University in Chicago and colleagues offer a snapshot of the cel
PAPER van Olst L, Simonton B, Edwards AJ, Forsyth AV, Boles J, Jamshidi P, Watson T, Shepard N, Krainc T, Argue BM, Zhang Z, Kuruvilla J, Camp L, Li M, Xu H, Norman JL, Cahan J, Vassar R, Chen J, Castellani RJ, Nicoll JA, Boche D, Gate D
COMMENT Mitochondria produce energy for our cells but are also prone to damage. How does the cell know when a mitochondrion is damaged? One way is through the PINK1-Parkin mitophagy pathway, with PINK1 serving as the damage sensor (reviewed in Narendra and Youle,
PAPER Kato H, Lu Q, Rapaport D, Kozjak-Pavlovic V
