PAPER Lin CH, Yang S, Huang YJ, Lane HY

Polymorphism in the LASP1 gene promoter region alters cognitive functions of patients with schizophrenia.

Sci Rep. 2019 Dec 11;9(1):18840. PubMed.

PAPER Hellwege JN, Keaton JM, Giri A, Gao X, Velez Edwards DR, Edwards TL

Population Stratification in Genetic Association Studies.

Curr Protoc Hum Genet. 2017 Oct 18;95:1.22.1-1.22.23. PubMed.

Joseph Therriault on Confirmed: Women Accumulate Tangles Faster Than Do Men

COMMENT Previous cross-sectional studies have indicated higher tau deposition in women, but there has been limited evidence from longitudinal studies suggesting females exhibit faster tau accumulation on average (Smith et al., 2020; Wang et al., 2024). This large

ASCB/EMBO Meeting: CELL BIO 25

CONFERENCE 2025-12-06 00:00:00-2025-12-10 00:00:00 Philadelphia, Pennsylvania 06 &#x2013 10 December 2025 View Conference Website 0

Marco Colonna on After Immunotherapy, Amyloid Clearance Comes Down to Microglial Moods

COMMENT This exciting study explores the role of microglia in immune-mediated clearing of Aβ plaques in AD. The study integrated spatial transcriptomics, proteogenomics, and scRNA-Seq to analyze postmortem brain tissues from AD patients who received active or pas

Giulia Albertini, Bart De Strooper on After Immunotherapy, Amyloid Clearance Comes Down to Microglial Moods

COMMENT In an era where anti-Aβ therapies are transitioning into widespread clinical practice, research into elucidating their working mechanisms, as well as their side effects, is crucial. Lynn van Olst, David Gate, and colleagues present a beautifully executed

PAPER Albertini A, Zielonka M, Cuypers ML, van Lieshout V, Snellinx A, Pasciuto E, Wolfs L, Craessaerts K, Horré K, Jaspers T, Fiers M, Dewilde M, De Strooper B

Using anti‐Aβ antibodies to modulate the multi‐pronged human microglia response to Aβ pathology

Alzheimers Dement. 2025 Jan 3 . Alzheimers & Dementia

Cynthia Lemere on After Immunotherapy, Amyloid Clearance Comes Down to Microglial Moods

COMMENT These studies allow an initial glimpse into the microglial response and Aβ removal following active Aβ vaccination and passive AŴ immunization. The following caveats should be kept in mind: AN1792 patients were immunized with full-length Aβ1-42 and a stro

PAPER Holste K, Xia F, Garton HJ, Wan S, Hua Y, Keep RF, Xi G

The role of complement in brain injury following intracerebral hemorrhage: A review.

Exp Neurol. 2021 Jun;340:113654. Epub 2021 Feb 20 PubMed.

Lis de Weerd, Christian Haass on After Immunotherapy, Amyloid Clearance Comes Down to Microglial Moods

COMMENT This paper is a key contribution, with far-reaching implications for the understanding of anti-amyloid antibody-based immunotherapies and the crucial role of microglial activity in efficient amyloid clearance. The authors identified significant unique and

After Immunotherapy, Amyloid Clearance Comes Down to Microglial Moods

RESEARCH NEWS 2025-03-14 Research News Plaques all but vanish in response to some Aβ immunotherapies. Scientists suspect microglia orchestrate the mop-up, but don’t know how, exactly. Now, David Gate of Northwestern University in Chicago and colleagues offer a snapshot of the cel

PAPER van Olst L, Simonton B, Edwards AJ, Forsyth AV, Boles J, Jamshidi P, Watson T, Shepard N, Krainc T, Argue BM, Zhang Z, Kuruvilla J, Camp L, Li M, Xu H, Norman JL, Cahan J, Vassar R, Chen J, Castellani RJ, Nicoll JA, Boche D, Gate D

Microglial mechanisms drive amyloid-β clearance in immunized patients with Alzheimer's disease.

Nat Med. 2025 Mar 6; Epub 2025 Mar 6 PubMed.

Derek Narendra on Pretty in PINK1, Cryo-EM Reveals How Kinase Anchors to Mitochondria

COMMENT Mitochondria produce energy for our cells but are also prone to damage. How does the cell know when a mitochondrion is damaged? One way is through the PINK1-Parkin mitophagy pathway, with PINK1 serving as the damage sensor (reviewed in Narendra and Youle,

PAPER Kato H, Lu Q, Rapaport D, Kozjak-Pavlovic V

Tom70 is essential for PINK1 import into mitochondria.

PLoS One. 2013;8(3):e58435. Epub 2013 Mar 5 PubMed.

Miratul Muqit on Pretty in PINK1, Cryo-EM Reveals How Kinase Anchors to Mitochondria

COMMENT More than a decade ago, Youle, Lazarou, and Matsuda first showed biochemically that human PINK1 is stabilized on the mitochondrial TOM complex. Since then, there has been great interest in understanding the mechanism. This new cryo-EM structure represents