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CONFERENCE COVERAGE 1998-07-19 Conference Coverage Alonso et al. (Abstract 590) reviewed the role of tau proteins in tubulin polymerization. There are six tau isoforms in the human brain. Three have three microtubule-binding domains (3R) and the three others have four microtubule-bindi
CONFERENCE COVERAGE 1998-07-18 Conference Coverage Perhaps one of the most striking features of the conference this year, reflecting the state of research on AD in general, is the continued absence of a clear consensus on what is the most relevant neuropathological change in AD. The fi
CONFERENCE COVERAGE 1998-07-18 Conference Coverage This session was disappointing, offering nothing really new. What new data were presented appear to be very controversial. Farrer et al. (Abstract 280) tried to confirm the linkage described by Duke University, North Carolina. They des
CONFERENCE COVERAGE 1998-07-18 Conference Coverage Soto (Abstract 295) presented data documenting the ability of their 11 and 5 amino-acid inhibitors to inhibit initial Aβ peptide aggregation and its ability to dissociate already formed Aβ fibrils in vitro. In addition to the assays me
CONFERENCE COVERAGE 1998-07-18 Conference Coverage Bruce Yankner took time out from his talk on Down's syndrome (Abstract 7) to discuss his recent injection studies in young versus aged rhesus monkeys, published in the July issue of Nature Medicine. His key findings were that inje
WEBINAR 1998-05-28 Chris Weihl led this live discussion on 28 May 1999. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Article under discussion van Leeuwen FW, de Kleijn DPV, van den Hurk HH, Neubauer A, Sonnemans M
RESEARCH NEWS 1998-05-20 Research News The brains of Alzheimer's disease victims are peppered with neuritic plaques-microscopic, spherical structures containing, among other things, deposits of β amyloid peptide, dead and dying neurons and evidence of inflammation. The infla
RESEARCH NEWS 1998-05-18 Research News Synucleins are small cytoplasmic proteins that are found in synaptic terminals. They are present in senile plaques and Lewy bodies (features of Alzheimer's disease and familial Parkinson's disease). Synucleins also bind amyloid pep
RESEARCH NEWS 1998-05-01 Research News (From Nature Biotechnology press release.) Each cell in our bodies contains 46 chromosomes. But one day far in the future, doctors may give us an extra miniature chromosome containing therapeutic genes to treat disease. Researchers are curre
RESEARCH NEWS 1998-04-09 Research News Breeding “knockout” mice is a prized tool for evaluating the function of genes, but it is a ponderous and costly tool, consuming many months and thousands of dollars to create each new knockout strain. But that could soon change. In today’s
RESEARCH NEWS 1998-04-09 Research News A gene on the long arm of chromosome 6 has been linked to an inherited form of Parkinson’s disease, called autosomal recessive juvenile parkinsonism (AR-JP). The research team of Nobuyoshi Shimizu and colleagues at Keio University School of
WEBINAR 1998-03-20 Marc Paradis led this live discussion on 20 March 1998. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Paper under Discussion: Li JH, Xu M, Zhou H. Ma J. and Potter H. Alzheimer presenilins in the n
WEBINAR 1998-02-27 Peter T. Nelson led this live discussion on 27 February 1998. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Paper Under Discussion: Cheetham JE, Coleman PD, Chow N. Isolation of Single Immunohistoc
COMMUNITY NEWS 1998-02-23 Community News Scientists often complain that scientific journals take too long to review manuscripts, and that subscription prices are unaffordable. A new journal devoted to Alzheimer's disease research, Alzheimer's Reports, aims to carve out a
WEBINAR 1998-01-30 Deborah Watson and Kenneth Kosik led this live discussion on 30 January 1998. Readers are invited to submit additional comments by using our Comments form at the bottom of the page. Paper Under Discussion: De Strooper B, Saftig P, Craessaerts K, Vandersti
