PAPER Salemme S, Lombardo FL, Lacorte E, Sciancalepore F, Remoli G, Bacigalupo I, Piscopo P, Zamboni G, Rossini PM, Cappa SF, Perani D, Spadin P, Tagliavini F, Vanacore N, Ancidoni A

The prognosis of mild cognitive impairment: A systematic review and meta-analysis.

Alzheimers Dement (Amst). 2025;17(1):e70074. Epub 2025 Mar 12 PubMed.

PAPER Kim C, Hovakimyan A, Zagorski K, Antonyan T, Petrushina I, Davtyan H, Chailyan G, Hasselmann J, Iba M, Adame A, Rockenstein E, Szabo M, Blurton-Jones M, Cribbs DH, Ghochikyan A, Masliah E, Agadjanyan MG

Retraction Note: Efficacy and immunogenicity of MultiTEP-based DNA vaccines targeting human α-synuclein: prelude for IND enabling studies.

NPJ Vaccines. 2025 Mar 12;10(1):47. PubMed. Retracted paper.

PAPER Li X, Pei R, Fei Z, Chen Z, Lin F, Sun P, Cao H

Could Blood Transfusion Increase the Risk of Alzheimer's Disease? A Narrative Review.

Healthcare (Basel). 2025 Feb 20;13(5) PubMed.

PAPER Taiyeb Khosroshahi M, Morsali S, Gharakhanlou S, Motamedi A, Hassanbaghlou S, Vahedi H, Pedrammehr S, Kabir HM, Jafarizadeh A

Explainable Artificial Intelligence in Neuroimaging of Alzheimer's Disease.

Diagnostics (Basel). 2025 Mar 4;15(5) PubMed.

PAPER

Mutant tau filaments from some inherited frontotemporal dementias show the Alzheimer fold.

Nat Struct Mol Biol. 2025 Mar 12; Epub 2025 Mar 12 PubMed.

PAPER Nakaya M, Kamagata K, Takabayashi K, Andica C, Uchida W, Hagiwara A, Akashi T, Wada A, Taoka T, Naganawa S, Abe O, Aoki S

Magnetic resonance imaging indices for early Alzheimer's disease detection: Brain clearance markers.

J Cereb Blood Flow Metab. 2025 Mar 13;:271678X251321305. Epub 2025 Mar 13 PubMed.

Aurore Delvenne on With Age, Macrophages Chew up the Blood-CSF Barrier

COMMENT The mechanisms underlying the disruption of the choroid plexus in aging and age-related neurodegenerative diseases remain relatively underexplored. In this insightful study, Chen et al. provide compelling evidence that macrophage activity plays a crucial

Tord Labuda

Alzinova AB
, Sweden

Stefan Pierrou

Alzinova AB
, Sweden

PAPER Alldred MJ, Ibrahim KW, Pidikiti H, Lee SH, Heguy A, Chiosis G, Mufson EJ, Stutzmann GE, Ginsberg SD

Profiling hippocampal neuronal populations reveals unique gene expression mosaics reflective of connectivity-based degeneration in the Ts65Dn mouse model of Down syndrome and Alzheimer's disease.

Front Mol Neurosci. 2025;18:1546375. Epub 2025 Feb 26 PubMed.

PAPER Sohur US, Gray DL, Duvvuri S, Zhang Y, Thayer K, Feng G

Phase 1 Parkinson's Disease Studies Show the Dopamine D1/D5 Agonist PF-06649751 is Safe and Well Tolerated.

Neurol Ther. 2018 Dec;7(2):307-319. Epub 2018 Oct 25 PubMed.

PAPER Gray DL, Allen JA, Mente S, O'Connor RE, DeMarco GJ, Efremov I, Tierney P, Volfson D, Davoren J, Guilmette E, Salafia M, Kozak R, Ehlers MD

Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor.

Nat Commun. 2018 Feb 14;9(1):674. PubMed.

Richard Ransohoff on With Age, Macrophages Chew up the Blood-CSF Barrier

COMMENT This paper focuses useful attention on the choroid plexus as a potential contributor to brain aging. The approach taken was to evaluate tight junctions of the CP epithelium, identifying claudin-1 (product of the CLDN1 gene) as declining in abundance with

PAPER Eyme KM, Sammarco A, Jha R, Mnatsakanyan H, Pechdimaljian C, Carvalho L, Neustadt R, Moses C, Alnasser A, Tardiff DF, Su B, Williams KJ, Bensinger SJ, Chung CY, Badr CE

Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models.

Sci Transl Med. 2023 Jan 18;15(679):eabq6288. Epub 2023 Jan 18 PubMed.

Fanny Ehret

, Germany