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COMMENT In an era where anti-Aβ therapies are transitioning into widespread clinical practice, research into elucidating their working mechanisms, as well as their side effects, is crucial. Lynn van Olst, David Gate, and colleagues present a beautifully executed
PAPER Albertini A, Zielonka M, Cuypers ML, van Lieshout V, Snellinx A, Pasciuto E, Wolfs L, Craessaerts K, Horré K, Jaspers T, Fiers M, Dewilde M, De Strooper B
COMMENT These studies allow an initial glimpse into the microglial response and Aβ removal following active Aβ vaccination and passive AŴ immunization. The following caveats should be kept in mind: AN1792 patients were immunized with full-length Aβ1-42 and a stro
PAPER Holste K, Xia F, Garton HJ, Wan S, Hua Y, Keep RF, Xi G
COMMENT This paper is a key contribution, with far-reaching implications for the understanding of anti-amyloid antibody-based immunotherapies and the crucial role of microglial activity in efficient amyloid clearance. The authors identified significant unique and
RESEARCH NEWS 2025-03-14 Research News Plaques all but vanish in response to some Aβ immunotherapies. Scientists suspect microglia orchestrate the mop-up, but don’t know how, exactly. Now, David Gate of Northwestern University in Chicago and colleagues offer a snapshot of the cel
PAPER van Olst L, Simonton B, Edwards AJ, Forsyth AV, Boles J, Jamshidi P, Watson T, Shepard N, Krainc T, Argue BM, Zhang Z, Kuruvilla J, Camp L, Li M, Xu H, Norman JL, Cahan J, Vassar R, Chen J, Castellani RJ, Nicoll JA, Boche D, Gate D
COMMENT Mitochondria produce energy for our cells but are also prone to damage. How does the cell know when a mitochondrion is damaged? One way is through the PINK1-Parkin mitophagy pathway, with PINK1 serving as the damage sensor (reviewed in Narendra and Youle,
PAPER Kato H, Lu Q, Rapaport D, Kozjak-Pavlovic V
COMMENT More than a decade ago, Youle, Lazarou, and Matsuda first showed biochemically that human PINK1 is stabilized on the mitochondrial TOM complex. Since then, there has been great interest in understanding the mechanism. This new cryo-EM structure represents
RESEARCH NEWS 2025-03-14 Research News A Parkinsonian mystery—how PINK1 locks onto malfunctioning mitochondria—now has a structural solution. Researchers at the University of Melbourne led by Sylvie Callegari, Alisa Glukhova, and David Komander have captured the first cryo-EM sna
PAPER Callegari S, Kirk NS, Gan ZY, Dite T, Cobbold SA, Leis A, Dagley LF, Glukhova A, Komander D
, Spain
PAPER Tagliaferro G, Davighi MG, Clemente F, Turchi F, Schiavina M, Matassini C, Goti A, Morrone A, Pierattelli R, Cardona F, Felli IC
PAPER Han MN, Di Natale MR, Lei E, Furness JB, Finkelstein DI, Hao MM, Diwakarla S, McQuade RM
