348526 RESULTS
RESEARCH NEWS 2001-03-15 Research News (From Science press release.) A British and German team has made the surprising discovery that the cell's mitochondria can export peptides into their surrounding environments [reported in tomorrow's issue of Science]. Much is known
RESEARCH NEWS 2001-03-09 Research News [From Nature press release] Understanding the mechanisms regulating brain wiring has until now relied on biochemical purification approaches in vertebrates and genetic approaches in invertebrates to identify molecular clues. This week Marc T
RESEARCH NEWS 2001-03-09 Research News [From Nature press release.] This week Peter Chien and Jonathan Weissman of the University of California, San Francisco, explain how they used two species of yeast (Candida albicans and Saccharomyces cerevisae) and an artificial yeast prion
RESEARCH NEWS 2001-03-07 Research News Aggregated proteins, or amyloids, are seen in a wide variety of neurodegenerative diseases, including Alzheimer's and Creutzfeldt-Jakob (CJD) disease. Such aggregates are generally considered to be aberrant formations, but a new study s
COMMUNITY NEWS 2001-03-05 Community News On February 28, 2001, the U.S. Food and Drug Administration (FDA) approved Reminyl® (galantamine hydrobromide) for the treatment of mild to moderate Alzheimer's disease. Data from placebo-controlled, double-blind clinical trials involv
RESEARCH NEWS 2001-02-27 Research News The most promising target for an Alzheimer's therapy in the short term may be the enzyme β-secretase, suggest two papers in the March issue of Nature Neuroscience. Two separate groups have found that mice lacking the BACE1 isoform of β-
RESEARCH NEWS 2001-02-26 Research News Deleting a critical gene for iron metabolism leads to selective neurodegeneration, according to a study in this month's Nature Genetics. When researchers, led by Tracey Rouault and Timothy La Vaute of the U.S. National Institute of Chil
COMMENT Question: Are Alzheimer's Disease and "Senile Dementia" the Same Disease? This perhaps is the most important "nomenclature" problem. AD used to refer to "pre-senile" dementia (PSD; middle age dementia). This name clearly
RESEARCH NEWS 2001-02-21 Research News The Memory Evaluation and Treatment Service at Burke Medical Research Institute in New York has started a therapeutic trial of a nutritional supplement-a "metabolic enhancer"-in nondiabetic AD patients who are also taking 10 mg/day
COMMUNITY NEWS 2001-02-13 Community News A Phase I clinical trial of growth factor gene therapy for Alzheimer's disease is currently in progress at the University of California, San Diego. The Investigators are Mark H. Tuszynski, Leon Thal, and Ben U. In this trial, patients&
COMMUNITY NEWS 2001-02-10 Community News According to a "Dear Healthcare Provider" letter dated January 26 and posted this week on the Web site of the U.S. Food and Drug Administration, patients who take breaks in Exelon (rivastigmine tartrate) therapy for longer than ab
RESEARCH NEWS 2001-02-07 Research News Stem cell researchers know only too well that most adult neural precursor cells differentiate into astrocytes, not the coveted nerve cells. Even when stimulated by the addition of neuron-inducing growth factors, such as PDGF or NT-3, only a
RESEARCH NEWS 2001-02-07 Research News A drug currently approved by the FDA for the treatment of dry mouth in Sjogren's syndrome (an autoimmune disease that affects excorine glands) has been shown to reduce levels of amyloid-β (Aβ) peptide in the cerebral spinal fluid of Alz
COMMENT Saido's team (Iwata et al.) infused labeled Aβ1-42 into rat hippocampus and found it was metabolized with a half-life of 39 minutes. They tried many classes of peptide inhibitors and found that neprilysin type were the only ones that prevented the br
RESEARCH NEWS 2001-02-06 Research News The enzyme neprilysin-capable of degrading Aβ42 peptide-is a new player in the Alzheimer's disease mystery. Writing in Neuroscience Letters, Patrick McGeer's group at the University of British Columbia adds critical circumstantial
